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    DUR12 bifunctional urea carboxylase/allophanate hydrolase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852507, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DUR12
    Official Full Name
    bifunctional urea carboxylase/allophanate hydrolase
    Primary source
    SGD:S000000412
    Locus tag
    YBR208C
    See related
    AllianceGenome:SGD:S000000412; FungiDB:YBR208C; VEuPathDB:YBR208C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DUR80
    Summary
    Enables allophanate hydrolase activity and urea carboxylase activity. Involved in urea catabolic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in 3-methylcrotonyl-CoA carboxylase 1 deficiency. Orthologous to human MCCC1 (methylcrotonyl-CoA carboxylase subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DUR12 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (636703..642210, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene mannosyltransferase KTR3 Neighboring gene Fth1p Neighboring gene uncharacterized protein Neighboring gene tRNA-Cys

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ty insertions upstream and downstream of native DUR1,2 promoter elements generate different patterns of DUR1,2 expression in Saccharomyces cerevisiae. Chisholm GE, et al. J Bacteriol, 1992 Apr. PMID 1313414, Free PMC Article
    2. The urea amidolyase (DUR1,2) gene of Saccharomyces cerevisiae. Genbauffe FS, et al. DNA Seq, 1991. PMID 1802034
    3. Induction and repression of the urea amidolyase gene in Saccharomyces cerevisiae. Genbauffe FS, et al. Mol Cell Biol, 1986 Nov. PMID 3025621, Free PMC Article
    4. Urea carboxylase and allophanate hydrolase. Two components of adenosine triphosphate:urea amido-lyase in Saccharomyces cerevisiae. Whitney PA, et al. J Biol Chem, 1972 Mar 10. PMID 4551940
    5. Urea carboxylase and allophanate hydrolase: two components of a multienzyme complex in Saccharomyces cerevisiae. Whitney PA, et al. Biochem Biophys Res Commun, 1972 Oct 6. PMID 4562164

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables allophanate hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables allophanate hydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables urea carboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables urea carboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables urea carboxylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in allantoin catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in small molecule metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in urea catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in urea catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 

    General protein information

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    Preferred Names
    bifunctional urea carboxylase/allophanate hydrolase
    NP_009767.1
    • Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      636703..642210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178556.1 → NP_009767.1  TPA: bifunctional urea carboxylase/allophanate hydrolase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009767.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQK5, P32528
      UniProtKB/TrEMBL
      C7GKH0, G2W9L2
      Conserved Domains (2) summary
      TIGR02712
      Location:633 → 1832
      urea_carbox; urea carboxylase
      TIGR02713
      Location:49 → 620
      allophanate_hyd; allophanate hydrolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32528.2

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