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    THI7 thiamine transporter THI7 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850938, updated on 9-Dec-2024

    Summary

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    Official Symbol
    THI7
    Official Full Name
    thiamine transporter THI7
    Primary source
    SGD:S000004227
    Locus tag
    YLR237W
    See related
    AllianceGenome:SGD:S000004227; FungiDB:YLR237W; VEuPathDB:YLR237W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    THI10
    Summary
    Enables 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transporter activity and thiamine transmembrane transporter activity. Involved in 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport and thiamine transport. Located in plasma membrane. Used to study megaloblastic anemia. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See THI7 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (612367..614163)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene DNA topoisomerase 3 Neighboring gene uncharacterized protein Neighboring gene Far10p Neighboring gene lipoyl(octanoyl) transferase LIP2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Defective high-affinity thiamine transporter leads to cell death in thiamine-responsive megaloblastic anemia syndrome fibroblasts. Stagg AR, et al. J Clin Invest, 1999 Mar. PMID 10074490, Free PMC Article
    2. Identification and characterization of the thiamine transporter gene of Saccharomyces cerevisiae. Singleton CK. Gene, 1997 Oct 15. PMID 9358046
    3. Thiamine increases the resistance of baker's yeast Saccharomyces cerevisiae against oxidative, osmotic and thermal stress, through mechanisms partly independent of thiamine diphosphate-bound enzymes. Wolak N, et al. FEMS Yeast Res, 2014 Dec. PMID 25331172
    4. Isolation and characterization of a thiamin transport gene, THI10, from Saccharomyces cerevisiae. Enjo F, et al. J Biol Chem, 1997 Aug 1. PMID 9235906
    5. Multi-gene phylogenetic analysis reveals that shochu-fermenting Saccharomyces cerevisiae strains form a distinct sub-clade of the Japanese sake cluster. Futagami T, et al. Yeast, 2017 Oct. PMID 28703391

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Art2 is the key regulator of ubiquitylation-dependent endocytosis of plasma membrane vitamin B1 transporters, Thi7, Nrt1, and Thi72.
      Title: Yeast α-arrestin Art2 is the key regulator of ubiquitylation-dependent endocytosis of plasma membrane vitamin B1 transporters.
    2. In this study,the authors performed the first phylogenetic classification of shochu strains using the nucleotide sequences of genes that reflect genome-level phylogeny. The single-nucleotide polymorphisms information identified in the present study is expected to be useful for distinguishing shochu yeast strains as part of quality control at shochu breweries.
      Title: Multi-gene phylogenetic analysis reveals that shochu-fermenting Saccharomyces cerevisiae strains form a distinct sub-clade of the Japanese sake cluster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables nucleobase transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiamine transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables thiamine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nucleobase transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in thiamine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thiamine transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in thiamine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    thiamine transporter THI7
    NP_013338.1
    • Plasma membrane transporter responsible for the uptake of thiamine; contributes to uptake of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (acadesine); member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      612367..614163
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182124.1 → NP_013338.1  TPA: thiamine transporter THI7 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013338.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYN5, P87335, Q05998
      UniProtKB/TrEMBL
      A7A1C0, B3RHC2, C7GQZ9, C8ZDK0, N1P1D9
      Conserved Domains (1) summary
      cd11482
      Location:27 → 505
      SLC-NCS1sbd_NRT1-like; nucleobase-cation-symport-1 (NCS1) transporter NRT1-like; solute-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05998.1

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