SAL1 Ca(2+)-binding ATP:ADP antiporter SAL1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: SAL1
Official Full Name: Ca(2+)-binding ATP:ADP antiporter SAL1
Primary source: SGD:S000005027
Locus tag: YNL083W
See related: AllianceGenome:SGD:S000005027; FungiDB:YNL083W; VEuPathDB:YNL083W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables ATP:ADP antiporter activity and calcium ion binding activity. Involved in ADP transport; ATP transport; and mitochondrial transport. Located in mitochondrion. Orthologous to several human genes including SLC25A23 (solute carrier family 25 member 23). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

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Growth on glucose requires ATP hydrolysis in mitochondria and recruits Sal1p as a Ca2+-dependent mechanism to import ATP-Mg from the cytosol.
Title: Yeast mitochondria import ATP through the calcium-dependent ATP-Mg/Pi carrier Sal1p, and are ATP consumers during aerobic growth in glucose.
Pleiotropic effects of the yeast Sal1 and Aac2 carriers on mitochondrial function via an activity distinct from adenine nucleotide transport.
Title: Pleiotropic effects of the yeast Sal1 and Aac2 carriers on mitochondrial function via an activity distinct from adenine nucleotide transport.
The transport activity of Sal1 and its sensitivity to a glucose-induced calcium signal are presented.
Title: The calcium-dependent ATP-Mg/Pi mitochondrial carrier is a target of glucose-induced calcium signalling in Saccharomyces cerevisiae.
Aac2p and Sal1p may define two parallel pathways that transport a nucleotide substrate in an operational mode distinct from ADP/ATP exchange.
Title: Sal1p, a calcium-dependent carrier protein that suppresses an essential cellular function associated With the Aac2 isoform of ADP/ATP translocase in Saccharomyces cerevisiae.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP:ADP antiporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ADP transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in ADP transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ATP transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in ATP transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_014316.3

ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains

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