MSP1 Msp1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MSP1
Official Full Name: Msp1p
Primary source: SGD:S000003260
Locus tag: YGR028W
See related: AllianceGenome:SGD:S000003260; FungiDB:YGR028W; VEuPathDB:YGR028W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: YTA4
Summary: Predicted to enable ATP hydrolysis activity. Involved in protein targeting to mitochondrion. Located in mitochondrial outer membrane and peroxisomal membrane. Human ortholog(s) of this gene implicated in hyperekplexia 4. Orthologous to human ATAD1 (ATPase family AAA domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MSP1 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (542203..543291)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ER-misfolded proteins become sequestered with mitochondria and impair mitochondrial function.
Title: ER-misfolded proteins become sequestered with mitochondria and impair mitochondrial function.
Msp1 functions as an extractase that mediates clearance of mistargeted tail anchored proteins by facilitating their transfer from mitochondria to endoplasmic reticulum for protein quality control.
Title: Msp1 Clears Mistargeted Proteins by Facilitating Their Transfer from Mitochondria to the ER.
In sum, this work argues that Msp1 selects its substrates on the basis of their solitary membrane existence.
Title: The AAA protein Msp1 mediates clearance of excess tail-anchored proteins from the peroxisomal membrane.
Report Msp1-dependent extraction of mislocalized TA proteins from the outer mitochondrial membrane.
Title: Msp1 Is a Membrane Protein Dislocase for Tail-Anchored Proteins.
Study suggests that the primary roles of Msp1p are to organize mitochondrial membranes, thus making them competent for fusion, and maintain the integrity of mtDNA.
Title: Loss of Msp1p in Schizosaccharomyces pombe induces a ROS-dependent nuclear mutator phenotype that affects mitochondrial fission genes.
Msp1 limits the accumulation of mislocalized tail-anchored proteins on mitochondria.
Title: Msp1/ATAD1 maintains mitochondrial function by facilitating the degradation of mislocalized tail-anchored proteins.
Our data suggest that Msp1 functions in local organelle surveillance by extracting mistargeted proteins, ensuring the fidelity of organelle specific-localization of tail anchored proteins.
Title: The conserved AAA-ATPase Msp1 confers organelle specificity to tail-anchored proteins.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in extraction of mislocalized protein from mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting to mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial outer membrane	HDA more info	PubMed
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in peroxisomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisomal membrane	IEA Inferred from Electronic Annotation more info
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Msp1p

NP_011542.3

Highly-conserved N-terminally anchored AAA-ATPase; distributed in the mitochondrial outer membrane and peroxisomes; involved in mitochondrial protein sorting; ATP-driven extractase that pulls mislocalized tail-anchored proteins into the cytosol, passing them to the GET pathway for transfer to the ER membrane for degradation, ensuring fidelity of organelle-specific localization of tail-anchored proteins; contains an N-terminal transmembrane domain and C-terminal cytoplasmic ATPase domain

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

542203..543291

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181157.3 → NP_011542.3 TPA: Msp1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011542.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VUG3, P28737

UniProtKB/TrEMBL

A6ZV16, B3LIJ2, B5VIY8, C7GK95, C8Z8S2, G2WEB8, N1P3F5

Conserved Domains (3) summary

COG5271
Location:10 → 164

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

pfam17862
Location:280 → 319

AAA_lid_3; AAA+ lid domain

cd19520
Location:92 → 255

RecA-like_ATAD1; ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains