GSH2 glutathione synthase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GSH2
Official Full Name: glutathione synthase
Primary source: SGD:S000005409
Locus tag: YOL049W
See related: AllianceGenome:SGD:S000005409; FungiDB:YOL049W; VEuPathDB:YOL049W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables glutathione synthase activity. Involved in glutathione biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Used to study Huntington's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; glutathione synthetase deficiency; glutathione synthetase deficiency of erythrocytes; and glutatione synthetase deficiency with 5-oxoprolinuria. Orthologous to human GSS (glutathione synthetase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See GSH2 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (238619..240094)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GSH1 and GSH2 gene mutations affect glutathione synthetase activity in Saccharomyces cerevisiae.
Title: Effects of GSH1 and GSH2 Gene Mutation on Glutathione Synthetases Activity of Saccharomyces cerevisiae.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables glutathione binding	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione synthase activity	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glutathione biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glutathione biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glutathione synthase

NP_014593.1

EC 6.3.2.3

Glutathione synthetase; catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

238619..240094

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183303.1 → NP_014593.1 TPA: glutathione synthase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014593.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W218, Q08220

UniProtKB/TrEMBL

B3LJ10, C7GK17, C8ZHR5, E9P9L9, N1P2R6

Conserved Domains (1) summary

TIGR01986
Location:11 → 490

glut_syn_euk; glutathione synthetase, eukaryotic