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    HVG1 putative GDP-mannose transporter [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856761, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HVG1
    Official Full Name
    putative GDP-mannose transporter
    Primary source
    SGD:S000000841
    Locus tag
    YER039C
    See related
    AllianceGenome:SGD:S000000841; FungiDB:YER039C; VEuPathDB:YER039C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YEM9
    Summary
    Predicted to enable GDP-mannose transmembrane transporter activity and antiporter activity. Predicted to be involved in GDP-mannose transmembrane transport. Located in endoplasmic reticulum. Orthologous to human TMEM241 (transmembrane protein 241). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HVG1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (228456..229205, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene bifunctional nucleotidase/lysophosphatidic acid phosphatase Neighboring gene Smc5-Smc6 complex subunit KRE29 Neighboring gene Fmp49p Neighboring gene uncharacterized protein Neighboring gene nitrogen-responsive transcriptional regulator GLN3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The VRG4 gene is required for GDP-mannose transport into the lumen of the Golgi in the yeast, Saccharomyces cerevisiae. Dean N, et al. J Biol Chem, 1997 Dec 12. PMID 9395539
    2. BSC2 induces multidrug resistance via contributing to the formation of biofilm in Saccharomyces cerevisiae. Huang Z, et al. Cell Microbiol, 2021 Dec. PMID 34482605
    3. A meiotic XPF-ERCC1-like complex recognizes joint molecule recombination intermediates to promote crossover formation. De Muyt A, et al. Genes Dev, 2018 Feb 1. PMID 29440262, Free PMC Article
    4. Systematic analysis of bypass suppression of essential genes. van Leeuwen J, et al. Mol Syst Biol, 2020 Sep. PMID 32939983, Free PMC Article
    5. The nucleotide sequence of Saccharomyces cerevisiae chromosome V. Dietrich FS, et al. Nature, 1997 May 29. PMID 9169868, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GDP-mannose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in GDP-mannose transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative GDP-mannose transporter
    NP_010956.1
    • hypothetical protein; HVG1 has a paralog, VRG4, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      228456..229205 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178930.1 → NP_010956.1  TPA: putative GDP-mannose transporter [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010956.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3LS51, B5VHH5, C7GSI5, D3DLT8, P0CE11, P40027, Q3E844
      Conserved Domains (1) summary
      COG5070
      Location:1 → 232
      VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CE11.1

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