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    PMP3 Pmp3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851869, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PMP3
    Official Full Name
    Pmp3p
    Primary source
    SGD:S000002684
    Locus tag
    YDR276C
    See related
    AllianceGenome:SGD:S000002684; FungiDB:YDR276C; VEuPathDB:YDR276C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SNA1
    Summary
    Enables phospholipid binding activity and sphingolipid binding activity. Involved in monoatomic cation transport and regulation of membrane potential. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PMP3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1013476..1013643, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene triglyceride-associated lipolysis regulator TLD1 Neighboring gene Mth1p Neighboring gene tRNA-Glu

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic and functional analysis of Arabidopsis RCI2 genes. Medina J, et al. J Exp Bot, 2007. PMID 18182435
    2. The low-temperature- and salt-induced RCI2A gene of Arabidopsis complements the sodium sensitivity caused by a deletion of the homologous yeast gene SNA1. Nylander M, et al. Plant Mol Biol, 2001 Feb. PMID 11292079
    3. Overexpression of PDR16 Confers Amphotericin B Resistance in a PMP3-Dependent Manner in Yeast Saccharomyces cerevisiae. Kalra S, et al. Microb Drug Resist, 2024 Jul. PMID 38727600
    4. Molecular characterization of a cold-induced plasma membrane protein gene from wheat. Koike M, et al. Mol Genet Genomics, 2005 Dec. PMID 16184390
    5. Functional responses between PMP3 small membrane proteins and membrane potential. Kwok ACM, et al. Environ Microbiol, 2020 Aug. PMID 32307863

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables phosphatidic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-3,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-3-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sphingolipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in monoatomic cation transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pmp3p
    NP_010562.1
    • Small plasma membrane protein; confers resistance to amphotericin B and is a potential target of this common antifungal drug; related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature; not essential for viability; deletion causes hyperpolarization of the plasma membrane potential

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1013476..1013643 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180584.1 → NP_010562.1  TPA: Pmp3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010562.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSQ7, P87284
      UniProtKB/TrEMBL
      A6ZYM6, B3LG17, C7GS94, C8Z5I9, G2WB16, N1P712
      Conserved Domains (1) summary
      pfam01679
      Location:5 → 53
      Pmp3; Proteolipid membrane potential modulator
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P87284.1

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