GPH1 glycogen phosphorylase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GPH1
Official Full Name: glycogen phosphorylase
Primary source: SGD:S000006364
Locus tag: YPR160W
See related: AllianceGenome:SGD:S000006364; FungiDB:YPR160W; VEuPathDB:YPR160W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables glycogen phosphorylase activity. Involved in glycogen catabolic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in glycogen storage disease; glycogen storage disease V; glycogen storage disease VI; and lactic acidosis. Orthologous to human PYGB (glycogen phosphorylase B); PYGL (glycogen phosphorylase L); and PYGM (glycogen phosphorylase, muscle associated). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See GPH1 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (861306..864014)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pho85p controls the phosphorylation state of glycogen phosphorylase
Title: Regulation of yeast glycogen phosphorylase by the cyclin-dependent protein kinase Pho85p.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 1,4-alpha-oligoglucan phosphorylase activity	IEA Inferred from Electronic Annotation more info
enables glycogen phosphorylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycogen phosphorylase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycogen phosphorylase activity	IEA Inferred from Electronic Annotation more info
enables glycogen phosphorylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables maltodextrin phosphorylase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycogen catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycogen catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycogen metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glycogen phosphorylase

NP_015486.1

EC 2.4.1.1

Glycogen phosphorylase required for the mobilization of glycogen; non-essential; regulated by cyclic AMP-mediated phosphorylation; phosphorylation by Cdc28p may coordinately regulate carbohydrate metabolism and the cell cycle; expression is regulated by stress-response elements and by the HOG MAP kinase pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

861306..864014

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184257.1 → NP_015486.1 TPA: glycogen phosphorylase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015486.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W4G1, P06738

UniProtKB/TrEMBL

A6ZX36, C8ZJI4, G2WPX3, N1NVM0

Conserved Domains (1) summary

cd04300
Location:68 → 898

GT35_Glycogen_Phosphorylase; glycogen phosphorylase and similar proteins