U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    NGR1 Ngr1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852513, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    NGR1
    Official Full Name
    Ngr1p
    Primary source
    SGD:S000000416
    Locus tag
    YBR212W
    See related
    AllianceGenome:SGD:S000000416; FungiDB:YBR212W; VEuPathDB:YBR212W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RBP1
    Summary
    Enables mRNA binding activity. Involved in 3'-UTR-mediated mRNA destabilization and mitochondrion organization. Located in P-body; cytoplasmic stress granule; and perinuclear region of cytoplasm. Orthologous to human HNRNPA0 (heterogeneous nuclear ribonucleoprotein A0). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See NGR1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (647886..649904)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Erv15p Neighboring gene Ame1p Neighboring gene bifunctional precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase MET8 Neighboring gene Sds24p

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. An RNA-binding protein gene (RBP1) of Saccharomyces cerevisiae encodes a putative glucose-repressible protein containing two RNA recognition motifs. Lee FJ, et al. J Biol Chem, 1993 Jul 15. PMID 8325883
    2. CTBP1/RBP1, a Saccharomyces cerevisiae protein which binds to T-rich single-stranded DNA containing the 11-bp core sequence of autonomously replicating sequence, is a poly(deoxypyrimidine)-binding protein. Ikeda M, et al. Eur J Biochem, 1996 May 15. PMID 8665950
    3. The yeast RNA-binding protein Rbp1p modifies the stability of mitochondrial porin mRNA. Buu LM, et al. J Biol Chem, 2004 Jan 2. PMID 14570877
    4. Determinants of Rbp1p localization in specific cytoplasmic mRNA-processing foci, P-bodies. Jang LT, et al. J Biol Chem, 2006 Sep 29. PMID 16885161
    5. Identification of genes affecting glucose catabolism in nitrogen-limited fermentation. Gardner JM, et al. FEMS Yeast Res, 2005 Jun. PMID 15925307

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding HDA PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA destabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in 3'-UTR-mediated mRNA destabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasmic stress granule HDA PubMed 
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Ngr1p
    NP_009771.3
    • RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; interacts with Dhh1p to mediate POR1 mRNA decay; expressed in stationary phase

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      647886..649904
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178560.3 → NP_009771.3  TPA: Ngr1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009771.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQK8, P32831
      UniProtKB/TrEMBL
      B3LMU8, C7GUY4, D3UEV8
      Conserved Domains (4) summary
      COG0724
      Location:308 → 526
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12346
      Location:359 → 430
      RRM3_NGR1_NAM8_like; RNA recognition motif 3 (RRM3) found in yeast negative growth regulatory protein NGR1 (RBP1), yeast protein NAM8 and similar proteins
      cd12611
      Location:35 → 180
      RRM1_NGR1_NAM8_like; RNA recognition motif 1 (RRM1) found in yeast negative growth regulatory protein NGR1, yeast protein NAM8 and similar proteins
      cd12613
      Location:191 → 270
      RRM2_NGR1_NAM8_like; RNA recognition motif 2 (RRM2) found in yeast negative growth regulatory protein NGR1, yeast protein NAM8 and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32831.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools