PEX7 Pex7p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PEX7
Official Full Name: Pex7p
Primary source: SGD:S000002549
Locus tag: YDR142C
See related: AllianceGenome:SGD:S000002549; FungiDB:YDR142C; VEuPathDB:YDR142C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PAS7; PEB1
Summary: Enables peroxisome matrix targeting signal-2 binding activity. Involved in protein import into peroxisome matrix, docking. Located in cytosol and peroxisome. Human ortholog(s) of this gene implicated in Peroxisome biogenesis disorder 9B and rhizomelic chondrodysplasia punctata type 1. Orthologous to human PEX7 (peroxisomal biogenesis factor 7). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PEX7 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (740473..741600, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data strongly suggest that the formation of the ternary cytosolic PTS2 pre-import complex occurs hierarchically.
Title: Peroxisomal targeting of PTS2 pre-import complexes in the yeast Saccharomyces cerevisiae.
appending GFP to Pex7p's COOH terminus shifts Pex7p's intracellular distribution from predominantly cytosolic to predominantly peroxisomal in Saccharomyces cerevisiae
Title: Pex7p translocates in and out of peroxisomes in Saccharomyces cerevisiae.
the C terminus of Pex14p contains distinct Pex5p and one Pex7p binding sites and the N terminus could be involved in a Pex5p-Pex14p association inside the peroxisomal membrane
Title: Yeast Pex14p possesses two functionally distinct Pex5p and one Pex7p binding sites.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables peroxisome matrix targeting signal-2 binding	IBA Inferred from Biological aspect of Ancestor more info
enables peroxisome matrix targeting signal-2 binding	IDA Inferred from Direct Assay more info	PubMed
enables peroxisome matrix targeting signal-2 binding	IEA Inferred from Electronic Annotation more info
enables peroxisome matrix targeting signal-2 binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in establishment of protein localization to peroxisome	IEA Inferred from Electronic Annotation more info
involved_in protein import into peroxisome matrix	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into peroxisome matrix	IEA Inferred from Electronic Annotation more info
involved_in protein import into peroxisome matrix, docking	IPI Inferred from Physical Interaction more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in peroxisomal matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisomal matrix	IEA Inferred from Electronic Annotation more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Pex7p

NP_010426.1

Peroxisomal signal receptor for peroxisomal matrix proteins; recognizes the N-terminal nonapeptide signal (PTS2); WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

740473..741600 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180449.1 → NP_010426.1 TPA: Pex7p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010426.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VSC5, P39108

UniProtKB/TrEMBL

A6ZYA2, C7GIP7, G2WAP2, N1P6E3

Conserved Domains (2) summary

sd00039
Location:65 → 102

7WD40; WD40 repeat [structural motif]

cl29593
Location:71 → 372

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...