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    RHO2 Rho family GTPase RHO2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855634, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RHO2
    Official Full Name
    Rho family GTPase RHO2
    Primary source
    SGD:S000005034
    Locus tag
    YNL090W
    See related
    AllianceGenome:SGD:S000005034; FungiDB:YNL090W; VEuPathDB:YNL090W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables GTPase activity. Predicted to be involved in actin filament organization; regulation of actin cytoskeleton organization; and signal transduction. Located in membrane. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to human RHOA (ras homolog family member A); RHOB (ras homolog family member B); and RHOC (ras homolog family member C). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RHO2 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (456565..457143)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene S-adenosylmethionine-dependent methyltransferase Neighboring gene Nst1p Neighboring gene DNA topoisomerase 2 Neighboring gene tricalbin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cell polarity and morphogenesis in budding yeast. Madden K, et al. Annu Rev Microbiol, 1998. PMID 9891811
    2. Characterization of two members of the rho gene family from the yeast Saccharomyces cerevisiae. Madaule P, et al. Proc Natl Acad Sci U S A, 1987 Feb. PMID 3543936, Free PMC Article
    3. MSS4, a phosphatidylinositol-4-phosphate 5-kinase required for organization of the actin cytoskeleton in Saccharomyces cerevisiae. Desrivières S, et al. J Biol Chem, 1998 Jun 19. PMID 9624178
    4. RHO gene products, putative small GTP-binding proteins, are important for activation of the CAL1/CDC43 gene product, a protein geranylgeranyltransferase in Saccharomyces cerevisiae. Qadota H, et al. Yeast, 1992 Sep. PMID 1441750
    5. Dissecting the architecture of a quantitative trait locus in yeast. Steinmetz LM, et al. Nature, 2002 Mar 21. PMID 11907579

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in establishment of cell polarity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in fungal-type cell wall organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in microtubule-based process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small GTPase-mediated signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rho family GTPase RHO2
    NP_014309.3
    • Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; involved in the establishment of cell polarity and in microtubule assembly

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      456565..457143
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182928.3 → NP_014309.3  TPA: Rho family GTPase RHO2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014309.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W190, P06781, Q45TZ2
      UniProtKB/TrEMBL
      A6ZRZ1, B3LNU8, C7GUN9, C8ZGE1, G2WM15, N1NZF7, Q7LM87, Q7LMA1
      Conserved Domains (1) summary
      cd04129
      Location:7 → 191
      Rho2; Ras homology family 2 (Rho2) of small guanosine triphosphatases (GTPases)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06781.2

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