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    PTH4 Pth4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854035, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PTH4
    Official Full Name
    Pth4p
    Primary source
    SGD:S000005474
    Locus tag
    YOL114C
    See related
    AllianceGenome:SGD:S000005474; FungiDB:YOL114C; VEuPathDB:YOL114C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables aminoacyl-tRNA hydrolase activity. Involved in mitochondrial translation. Part of mitochondrial large ribosomal subunit. Orthologous to human MRPL58 (mitochondrial ribosomal protein L58). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PTH4 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (103317..103925, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Msn1p Neighboring gene non-canonical poly(A) polymerase PAP2 Neighboring gene putative serine/threonine protein kinase SKM1 Neighboring gene Rab GTPase-activating protein MSB4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A stalled-ribosome rescue factor Pth3 is required for mitochondrial translation against antibiotics in Saccharomyces cerevisiae. Hoshino S, et al. Commun Biol, 2021 Mar 8. PMID 33686140, Free PMC Article
    2. Proteomic profiling of the mitochondrial ribosome identifies Atp25 as a composite mitochondrial precursor protein. Woellhaf MW, et al. Mol Biol Cell, 2016 Oct 15. PMID 27582385, Free PMC Article
    3. Organization of Mitochondrial Gene Expression in Two Distinct Ribosome-Containing Assemblies. Kehrein K, et al. Cell Rep, 2015 Feb 17. PMID 25683707
    4. Fungal BLAST and Model Organism BLASTP Best Hits: new comparison resources at the Saccharomyces Genome Database (SGD). Balakrishnan R, et al. Nucleic Acids Res, 2005 Jan 1. PMID 15608219, Free PMC Article
    5. A genetic screen for high copy number suppressors of the synthetic lethality between elg1Δ and srs2Δ in yeast. Gazy I, et al. G3 (Bethesda), 2013 May 20. PMID 23704284, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables aminoacyl-tRNA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aminoacyl-tRNA hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation release factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation release factor activity, codon nonspecific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial translational termination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational termination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mitochondrial large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pth4p
    NP_014527.1
    • Stalled-ribosome rescue factor srRF1; similar to human peptidyl-tRNA hydrolase ICT1; associates with mitochondrial large subunit; not an essential gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      103317..103925 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183368.1 → NP_014527.1  TPA: Pth4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014527.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1V3, Q12322
      UniProtKB/TrEMBL
      A6ZN96, B3LIV1, B5VRE2, C7GSS2, C8ZHK1, G2WMC2, N1NX23
      Conserved Domains (1) summary
      COG1186
      Location:1 → 200
      PrfB; Protein chain release factor B [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12322.1

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