GAL11 Gal11p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GAL11
Official Full Name: Gal11p
Primary source: SGD:S000005411
Locus tag: YOL051W
See related: AllianceGenome:SGD:S000005411; FungiDB:YOL051W; VEuPathDB:YOL051W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ABE1; MED15; RAR3; SDS4; SPT13
Summary: Enables RNA polymerase II general transcription initiation factor binding activity; RNA polymerase II-specific DNA-binding transcription factor binding activity; and transcription coactivator activity. Involved in several processes, including RNA polymerase II preinitiation complex assembly; positive regulation of invasive growth in response to glucose limitation; and regulation of transcription by RNA polymerase II. Part of core mediator complex. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See GAL11 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (234940..238185)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Growth-regulated co-occupancy of Mediator and Lsm3 at intronic ribosomal protein genes.
Title: Growth-regulated co-occupancy of Mediator and Lsm3 at intronic ribosomal protein genes.
Mediator subunit Med15 dictates the conserved ""fuzzy"" binding mechanism of yeast transcription activators Gal4 and Gcn4.
Title: Mediator subunit Med15 dictates the conserved "fuzzy" binding mechanism of yeast transcription activators Gal4 and Gcn4.
The Polymorphic PolyQ Tail Protein of the Mediator Complex, Med15, Regulates the Variable Response to Diverse Stresses.
Title: The Polymorphic PolyQ Tail Protein of the Mediator Complex, Med15, Regulates the Variable Response to Diverse Stresses.
Med15: Glutamine-Rich Mediator Subunit with Potential for Plasticity.
Title: Med15: Glutamine-Rich Mediator Subunit with Potential for Plasticity.
Authors find that the large Gcn4-Med15 complex is heterogeneous and contains nearly all possible AD-ABD interactions. Gcn4-Med15 forms via a dynamic fuzzy protein-protein interface, where ADs bind the ABDs in multiple orientations via hydrophobic regions that gain helicity.
Title: Gcn4-Mediator Specificity Is Mediated by a Large and Dynamic Fuzzy Protein-Protein Complex.
The central activation domain (cAD) of Gcn4 functions through a sequence-specific motif. Optimizing this motif by inserting additional hydrophobic residues creates ADs that bind the Mediator subunit Gal11 via a "fuzzy" protein interface.
Title: A sequence-specific transcription activator motif and powerful synthetic variants that bind Mediator using a fuzzy protein interface.
Mediator recruitment to heat shock genes requires dual Hsf1 activation domains and mediator tail subunits Med15 and Med16.
Title: Mediator recruitment to heat shock genes requires dual Hsf1 activation domains and mediator tail subunits Med15 and Med16.
Phosphorylated sites in the Mediator tail subunit Med15 are required for suppression of stress-induced changes in gene expression under non-stress conditions.
Title: Mediator phosphorylation prevents stress response transcription during non-stress conditions.
Existence of a novel role for Tel2, namely in transcription, possibly in cooperation with Rvb2 and involving the existence of physical interactions with the Med15/Gal11 Mediator subunit.
Title: Genetic and physical interactions between Tel2 and the Med15 Mediator subunit in Saccharomyces cerevisiae.
Data show that the conserved Gal11 KIX domain contributes to Gal11 function, but found no evidence of specific Gcn4-KIX interaction and conclude that the Gal11 KIX domain does not function by specific interaction with Gcn4.
Title: Mechanism of Mediator recruitment by tandem Gcn4 activation domains and three Gal11 activator-binding domains.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	IDA Inferred from Direct Assay more info	PubMed
enables TFIIE-class transcription factor complex binding	IDA Inferred from Direct Assay more info	PubMed
enables TFIIH-class transcription factor complex binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription coregulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA polymerase II preinitiation complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of invasive growth in response to glucose limitation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of establishment of protein localization to chromosome	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of establishment of protein localization to chromosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of core mediator complex	IDA Inferred from Direct Assay more info	PubMed
part_of mediator complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Gal11p

NP_014591.1

Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

234940..238185

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183305.1 → NP_014591.1 TPA: Gal11p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014591.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W217, P19659, Q08221

UniProtKB/TrEMBL

B3LJ09, N1NWC1

Conserved Domains (3) summary

pfam05397
Location:509 → 620

Med15_fungi; Mediator complex subunit 15

pfam16987
Location:9 → 80

KIX_2; KIX domain

cl17096
Location:170 → 232

gal11_coact; gall11 coactivator domain