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    NSE3 Smc5-Smc6 complex subunit NSE3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851882, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NSE3
    Official Full Name
    Smc5-Smc6 complex subunit NSE3
    Primary source
    SGD:S000002696
    Locus tag
    YDR288W
    See related
    AllianceGenome:SGD:S000002696; FungiDB:YDR288W; VEuPathDB:YDR288W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to SUMO transferase activity. Involved in DNA repair. Located in cytoplasm and nucleus. Part of Smc5-Smc6 complex. Human ortholog(s) of this gene implicated in Prader-Willi syndrome. Orthologous to several human genes including MAGEB1 (MAGE family member B1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NSE3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1037195..1038106)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Mgp12p Neighboring gene inositol monophosphate 1-phosphatase INM2 Neighboring gene Rtt103p Neighboring gene ATP-dependent 3'-5' DNA helicase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Smc5/6 Is a Telomere-Associated Complex that Regulates Sir4 Binding and TPE. Moradi-Fard S, et al. PLoS Genet, 2016 Aug. PMID 27564449, Free PMC Article
    2. Interaction of the Saccharomyces cerevisiae RING-domain protein Nse1 with Nse3 and the Smc5/6 complex is required for chromosome replication and stability. Wani S, et al. Curr Genet, 2018 Jun. PMID 29119272
    3. The Smc5/6 complex is a DNA loop-extruding motor. Pradhan B, et al. Nature, 2023 Apr. PMID 37076626, Free PMC Article
    4. Architecture of the Smc5/6 Complex of Saccharomyces cerevisiae Reveals a Unique Interaction between the Nse5-6 Subcomplex and the Hinge Regions of Smc5 and Smc6. Duan X, et al. J Biol Chem, 2009 Mar 27. PMID 19141609, Free PMC Article
    5. Smc5/6 in the rDNA modulates lifespan independently of Fob1​. Moradi-Fard S, et al. Aging Cell, 2021 Jun. PMID 33979898, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. nse3-1/ sir4 Delta double mutants show additive defects for telomere shortening and TPE indicating the contribution of Smc5/6 to telomere homeostasis is only in partial overlap with SIR factor silencing. These findings support a role for Smc5/6 in telomere maintenance that is separate from its canonical role(s) in HR-mediated events during replication and telomere elongation.
      Title: Smc5/6 Is a Telomere-Associated Complex that Regulates Sir4 Binding and TPE.
    2. Smc5 and Smc6 associate with each other at their hinge regions and constitute the backbone of the complex, whereas the Nse1-6 subunits form three distinct subcomplexes/entities that interact with different regions of Smc5 and Smc6.
      Title: Architecture of the Smc5/6 Complex of Saccharomyces cerevisiae Reveals a Unique Interaction between the Nse5-6 Subcomplex and the Hinge Regions of Smc5 and Smc6.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to SUMO transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Smc5-Smc6 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Smc5-Smc6 complex subunit NSE3
    NP_010574.1
    • Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1037195..1038106
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180596.1 → NP_010574.1  TPA: Smc5-Smc6 complex subunit NSE3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010574.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSR8, Q05541
      UniProtKB/TrEMBL
      A6ZYN7, B3LG06, B5VGG4, N1P6T2
      Conserved Domains (1) summary
      pfam01454
      Location:31 → 269
      MAGE; MAGE family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05541.1

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