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    RRD2 peptidylprolyl isomerase RRD2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855951, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RRD2
    Official Full Name
    peptidylprolyl isomerase RRD2
    Primary source
    SGD:S000006073
    Locus tag
    YPL152W
    See related
    AllianceGenome:SGD:S000006073; FungiDB:YPL152W; VEuPathDB:YPL152W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YPA2
    Summary
    Enables peptidyl-prolyl cis-trans isomerase activity and protein phosphatase regulator activity. Involved in mitotic spindle organization and response to osmotic stress. Part of protein phosphatase type 2A complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RRD2 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (265028..266104)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene serine/threonine/tyrosine protein kinase RAD53 Neighboring gene uncharacterized protein Neighboring gene mRNA splicing protein PRP46 Neighboring gene non-specific serine/threonine protein kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The phosphotyrosyl phosphatase activator of protein phosphatase 2A. A novel purification method, immunological and enzymic characterization. Van Hoof C, et al. Eur J Biochem, 1994 Dec 15. PMID 7813481
    2. Anaerobic growth of Saccharomyces cerevisiae alleviates the lethal effect of phosphotyrosyl phosphatase activators depletion. Rempola B, et al. Acta Biochim Pol, 2001. PMID 11995966
    3. The Saccharomyces cerevisiae homologue YPA1 of the mammalian phosphotyrosyl phosphatase activator of protein phosphatase 2A controls progression through the G1 phase of the yeast cell cycle. Van Hoof C, et al. J Mol Biol, 2000 Sep 8. PMID 10964564
    4. Crystal structure of the PP2A phosphatase activator: implications for its PP2A-specific PPIase activity. Leulliot N, et al. Mol Cell, 2006 Aug 4. PMID 16885030
    5. Functional analysis of conserved domains in the phosphotyrosyl phosphatase activator. Molecular cloning of the homologues from Drosophila melanogaster and Saccharomyces cerevisiae. Van Hoof C, et al. Biochemistry, 1998 Sep 15. PMID 9737869

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. specific interaction of Rrd1 with the Tap42-Sit4 complex and that of Rrd2 with the Tap42-Phosphoprotein Phosphatase 2Ac complex
      Title: The yeast phosphotyrosyl phosphatase activator is part of the Tap42-phosphatase complexes.
    2. The crystal structures of Ypa2 was determined, revealing an all alpha-helical protein fold that is radically different from other PPIases.
      Title: Crystal structure of the PP2A phosphatase activator: implications for its PP2A-specific PPIase activity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peptidylprolyl isomerase RRD2
    NP_015173.1
    • Peptidyl-prolyl cis/trans-isomerase; also activates the phosphotyrosyl phosphatase activity of protein phosphatase 2A (PP2A); regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      265028..266104
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183966.1 → NP_015173.1  TPA: peptidylprolyl isomerase RRD2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015173.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3L7, Q12461
      UniProtKB/TrEMBL
      A6ZWA2, B3LKS6, C7GJA3, C8ZIM7, G2WP31, N1NVF9
      Conserved Domains (1) summary
      COG5057
      Location:1 → 358
      LAG1; Phosphotyrosyl phosphatase activator [Cell division and chromosome partitioning / Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12461.1

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