U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ARP8 Arp8p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854309, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ARP8
    Official Full Name
    Arp8p
    Primary source
    SGD:S000005667
    Locus tag
    YOR141C
    See related
    AllianceGenome:SGD:S000005667; FungiDB:YOR141C; VEuPathDB:YOR141C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mRNA binding activity. Involved in chromatin remodeling; double-strand break repair; and mitotic recombination. Located in nucleus. Part of Ino80 complex. Orthologous to human ACTR8 (actin related protein 8). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ARP8 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (589942..592587, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Rup1p Neighboring gene Sfl1p Neighboring gene succinate--CoA ligase (GDP-forming) subunit alpha Neighboring gene tRNA-Gly

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Exploring the functional landscape of gene expression: directed search of large microarray compendia. Hibbs MA, et al. Bioinformatics, 2007 Oct 15. PMID 17724061
    2. Effect of nuclear architecture on the efficiency of double-strand break repair. Agmon N, et al. Nat Cell Biol, 2013 Jun. PMID 23644470
    3. Structural biochemistry of nuclear actin-related proteins 4 and 8 reveals their interaction with actin. Fenn S, et al. EMBO J, 2011 Jun 1. PMID 21499228, Free PMC Article
    4. The INO80 complex is required for damage-induced recombination. Kawashima S, et al. Biochem Biophys Res Commun, 2007 Apr 13. PMID 17320816
    5. The INO80 chromatin remodeling complex functions in sister chromatid cohesion. Ogiwara H, et al. Cell Cycle, 2007 May 2. PMID 17471029

    See all (139) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arp8 engages N-actin in a manner distinct from that of other actin-fold proteins and thereby specifies recruitment of the Arp4-N-actin heterodimer to a segmented scaffold of the helicase-SANT-associated (HSA) domain of Ino80
      Title: The nuclear actin-containing Arp8 module is a linker DNA sensor driving INO80 chromatin remodeling.
    2. Interactions between the nucleosome histone core and Arp8 in the INO80 chromatin remodeling complex
      Title: Interactions between the nucleosome histone core and Arp8 in the INO80 chromatin remodeling complex.
    3. Remarkably, Arp4, assisted by Arp8, influences actin polymerization in vitro and is able to depolymerize actin filaments.
      Title: Structural biochemistry of nuclear actin-related proteins 4 and 8 reveals their interaction with actin.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Ino80 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ino80 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membraneless organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Arp8p
    NP_014784.1
    • Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; has mRNA binding activity

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      589942..592587 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183560.1 → NP_014784.1  TPA: Arp8p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014784.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2J7, Q12386
      UniProtKB/TrEMBL
      G2WN14
      Conserved Domains (2) summary
      smart00268
      Location:266 → 878
      ACTIN; Actin
      cl17037
      Location:42 → 447
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12386.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools