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    SLX1 endonuclease [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852529, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SLX1
    Official Full Name
    endonuclease
    Primary source
    SGD:S000000432
    Locus tag
    YBR228W
    See related
    AllianceGenome:SGD:S000000432; FungiDB:YBR228W; VEuPathDB:YBR228W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 5'-flap endonuclease activity. Involved in DNA-templated DNA replication. Part of Slx1-Slx4 complex. Orthologous to human SLX1A (SLX1 homolog A, structure-specific endonuclease subunit) and SLX1B (SLX1 homolog B, structure-specific endonuclease subunit). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SLX1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (675313..676227)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Mcx1p Neighboring gene glucan 1,3-alpha-glucosidase ROT2 Neighboring gene Om14p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure specific DNA recognition by the SLX1-SLX4 endonuclease complex. Xu X, et al. Nucleic Acids Res, 2021 Jul 21. PMID 34181713, Free PMC Article
    2. Slx1-Slx4 is a second structure-specific endonuclease functionally redundant with Sgs1-Top3. Fricke WM, et al. Genes Dev, 2003 Jul 15. PMID 12832395, Free PMC Article
    3. Overlapping roles for Yen1 and Mus81 in cellular Holliday junction processing. Tay YD, et al. J Biol Chem, 2010 Apr 9. PMID 20178992, Free PMC Article
    4. Assembly of Slx4 signaling complexes behind DNA replication forks. Balint A, et al. EMBO J, 2015 Aug 13. PMID 26113155, Free PMC Article
    5. Budding Yeast SLX4 Contributes to the Appropriate Distribution of Crossovers and Meiotic Double-Strand Break Formation on Bivalents During Meiosis. Higashide M, et al. G3 (Bethesda), 2016 Jul 7. PMID 27172214, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structure specific DNA recognition by the SLX1-SLX4 endonuclease complex.
      Title: Structure specific DNA recognition by the SLX1-SLX4 endonuclease complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 5'-flap endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-flap endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 5'-flap endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables crossover junction DNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated DNA replication IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Slx1-Slx4 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Slx1-Slx4 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Slx1-Slx4 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    endonuclease
    NP_009787.3
    • Endonuclease involved in DNA recombination and repair; subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      675313..676227
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178576.3 → NP_009787.3  TPA: endonuclease [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009787.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZLG6, D6VQM3, P38324
      UniProtKB/TrEMBL
      G2W9N0
      Conserved Domains (1) summary
      cd10455
      Location:13 → 87
      GIY-YIG_SLX1; Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its eukaryotic homologs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38324.1

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