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    HOM2 aspartate-semialdehyde dehydrogenase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851736, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HOM2
    Official Full Name
    aspartate-semialdehyde dehydrogenase
    Primary source
    SGD:S000002565
    Locus tag
    YDR158W
    See related
    AllianceGenome:SGD:S000002565; FungiDB:YDR158W; VEuPathDB:YDR158W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    THR2
    Summary
    Enables aspartate-semialdehyde dehydrogenase activity. Involved in homoserine biosynthetic process; methionine biosynthetic process; and threonine biosynthetic process. Located in cytoplasm; nucleus; and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HOM2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (770357..771454)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase CPR1 Neighboring gene DNA-directed RNA polymerase I subunit RPA14 Neighboring gene uncharacterized protein Neighboring gene Sac3p Neighboring gene Ssy1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of the HOM2 gene of Saccharomyces cerevisiae and regulation of its expression. Thomas D, et al. Mol Gen Genet, 1989 May. PMID 2570346
    2. Purification and characterization of aspartic -semialdehyde dehydrogenase from yeast and purification of an isozyme of glyceraldehyde-3-phosphate dehydrogenase. Holland MJ, et al. Biochemistry, 1973 Jun 5. PMID 4145650
    3. Simultaneous transport of different localized mRNA species revealed by live-cell imaging. Lange S, et al. Traffic, 2008 Aug. PMID 18485054
    4. Four major transcriptional responses in the methionine/threonine biosynthetic pathway of Saccharomyces cerevisiae. Mountain HA, et al. Yeast, 1991 Nov. PMID 1789001
    5. FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation. Arévalo-Rodríguez M, et al. Eukaryot Cell, 2004 Oct. PMID 15470257, Free PMC Article

    See all (86) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aspartate-semialdehyde dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aspartate-semialdehyde dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aspartate-semialdehyde dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in homoserine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lysine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methionine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in methionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methionine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in threonine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in threonine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in threonine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    aspartate-semialdehyde dehydrogenase
    NP_010442.3
    • Aspartic beta semi-aldehyde dehydrogenase; catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      770357..771454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180465.3 → NP_010442.3  TPA: aspartate-semialdehyde dehydrogenase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010442.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSD8, P13663
      UniProtKB/TrEMBL
      A6ZYB6, B3LGC6, B5VG51, C7GX38, C8Z573, G2WAQ6, N1P6P6
      Conserved Domains (1) summary
      PRK08664
      Location:7 → 365
      PRK08664; aspartate-semialdehyde dehydrogenase; Reviewed
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13663.1

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