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    CRT10 Crt10p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854091, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CRT10
    Official Full Name
    Crt10p
    Primary source
    SGD:S000005424
    Locus tag
    YOL063C
    See related
    AllianceGenome:SGD:S000005424; FungiDB:YOL063C; VEuPathDB:YOL063C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in nonfunctional rRNA decay. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CRT10 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (207392..210265, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene phosphoinositide 5-phosphatase INP54 Neighboring gene 3'(2'),5'-bisphosphate nucleotidase Neighboring gene Apm4p Neighboring gene ribose phosphate diphosphokinase subunit PRS5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of CRT10 as a novel regulator of Saccharomyces cerevisiae ribonucleotide reductase genes. Fu Y, et al. Nucleic Acids Res, 2006. PMID 16600900, Free PMC Article
    2. Rtt101 and Mms1 in budding yeast form a CUL4(DDB1)-like ubiquitin ligase that promotes replication through damaged DNA. Zaidi IW, et al. EMBO Rep, 2008 Oct. PMID 18704118, Free PMC Article
    3. 2'-O-ribose methylation of transfer RNA promotes recovery from oxidative stress in Saccharomyces cerevisiae. Endres L, et al. PLoS One, 2020. PMID 32053677, Free PMC Article
    4. Crt10 directs the cullin-E3 ligase Rtt101 to nonfunctional 25S rRNA decay. Sakata T, et al. Biochem Biophys Res Commun, 2015 Jan 30. PMID 25534857
    5. Remodeling of the SCF complex-mediated ubiquitination system by compositional alteration of incorporated F-box proteins. Kato M, et al. Proteomics, 2010 Jan. PMID 19882662

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CRT10 is involved in the transcriptional regulation of ribonucleotide reductase genes.
      Title: Identification and characterization of CRT10 as a novel regulator of Saccharomyces cerevisiae ribonucleotide reductase genes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in nonfunctional rRNA decay IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nonfunctional rRNA decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    Crt10p
    NP_014578.1
    • Protein required for the degradation of mutant 25S rRNAs; functions in Mms1 pathway of nonfunctional 25S rRNA decay; expression induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      207392..210265 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183318.1 → NP_014578.1  TPA: Crt10p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014578.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W204, Q08226, Q6B2N4, Q7LGP7
      UniProtKB/TrEMBL
      N1P431
      Conserved Domains (1) summary
      pfam08728
      Location:127 → 948
      CRT10
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08226.1

    Gene LinkOut

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