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    RPL1A ribosomal 60S subunit protein L1A [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855881, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RPL1A
    Official Full Name
    ribosomal 60S subunit protein L1A
    Primary source
    SGD:S000006141
    Locus tag
    YPL220W
    See related
    AllianceGenome:SGD:S000006141; FungiDB:YPL220W; VEuPathDB:YPL220W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PUB2; SSM1
    Summary
    Predicted to enable RNA binding activity. Involved in ribosomal large subunit export from nucleus. Part of cytosolic large ribosomal subunit. Orthologous to human RPL10A (ribosomal protein L10a). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RPL1A in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (135790..136443)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Fmp40p Neighboring gene flavin adenine dinucleotide transporter Neighboring gene Pcl8p Neighboring gene Arf family GTPase SAR1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Probing the yeast 5 S RNA-protein complex by fluorescence and controlled proteolytic digestion. Yeh LC, et al. Arch Biochem Biophys, 1990 Feb 1. PMID 2407192
    2. Yeast 5S rRNA binding to ribosomal protein L1a alters the fluorescence of tryptophan residues lying outside the binding site. Yeh LC, et al. Biochimie, 1992 Nov. PMID 1477137
    3. The accessibility of yeast ribosomal protein L1 as probed by proteolysis and site-directed mutagenesis is different in intact 60 and 80 S ribosome. Lee JC, et al. J Biol Chem, 1996 Mar 29. PMID 8631769
    4. The ABCF ATPase New1 resolves translation termination defects associated with specific tRNAArg and tRNALys isoacceptors in the P site. Turnbull K, et al. Nucleic Acids Res, 2024 Oct 28. PMID 39217469, Free PMC Article
    5. The duplicated Saccharomyces cerevisiae gene SSM1 encodes a eucaryotic homolog of the eubacterial and archaebacterial L1 ribosomal proteins. Petitjean A, et al. Mol Cell Biol, 1995 Sep. PMID 7651424, Free PMC Article

    See all (98) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IC
    Inferred by Curator
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in ribosomal large subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of large ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 60S subunit protein L1A
    NP_015104.1
    • Ribosomal 60S subunit protein L1A; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1A has a paralog, RPL1B, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal; ribosomes containing Rpl1b are more efficient in translation of respiration-related proteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      135790..136443
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184034.1 → NP_015104.1  TPA: ribosomal 60S subunit protein L1A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015104.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU14, P0CX43, P0CX44, P53030
      UniProtKB/TrEMBL
      A6ZU48, B3LHJ3, B5VIJ6, C7GN47, C8Z8B5, G2WDW8, G2WNW5, N1P598
      Conserved Domains (1) summary
      cl00322
      Location:1 → 217
      Ribosomal_L1; Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CX43.1
    P0CX44.1

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