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    SUR2 sphingosine hydroxylase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851891, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SUR2
    Official Full Name
    sphingosine hydroxylase
    Primary source
    SGD:S000002705
    Locus tag
    YDR297W
    See related
    AllianceGenome:SGD:S000002705; FungiDB:YDR297W; VEuPathDB:YDR297W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SYR2
    Summary
    Enables sphingosine hydroxylase activity. Involved in sphingolipid metabolic process. Located in endoplasmic reticulum membrane. Orthologous to human CH25H (cholesterol 25-hydroxylase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SUR2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1056551..1057600)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Hda2p Neighboring gene mitochondrial 54S ribosomal protein MHR1 Neighboring gene F1F0 ATP synthase subunit 5 Neighboring gene rRNA-processing protein BFR2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast genes involved in growth inhibition by Pseudomonas syringae pv. syringae syringomycin family lipodepsipeptides. Takemoto JY, et al. FEMS Microbiol Lett, 1993 Dec 15. PMID 8288110
    2. Syringomycin action gene SYR2 is essential for sphingolipid 4-hydroxylation in Saccharomyces cerevisiae. Grilley MM, et al. J Biol Chem, 1998 May 1. PMID 9556590
    3. Stereochemistry of a bifunctional dihydroceramide delta 4-desaturase/hydroxylase from Candida albicans; a key enzyme of sphingolipid metabolism. Beckmann C, et al. Org Biomol Chem, 2003 Jul 21. PMID 12956060
    4. Identification of fungal sphingolipid C9-methyltransferases by phylogenetic profiling. Ternes P, et al. J Biol Chem, 2006 Mar 3. PMID 16339149
    5. SYR2, a gene necessary for syringomycin growth inhibition of Saccharomyces cerevisiae. Cliften P, et al. Microbiology (Reading), 1996 Mar. PMID 8868422

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sphingolipid delta-4 desaturase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sphingosine hydroxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sphingosine hydroxylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingolipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingolipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sphingosine hydroxylase
    NP_010583.1
    • Sphinganine C4-hydroxylase; catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1056551..1057600
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180605.1 → NP_010583.1  TPA: sphingosine hydroxylase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010583.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSS6, P38992
      UniProtKB/TrEMBL
      B3LFZ8, B5VGH5, C7GQU7, C8Z5K9, G2WB35, N1P8K6
      Conserved Domains (1) summary
      COG3000
      Location:40 → 337
      ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38992.1

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