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    GOT1 Got1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855337, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GOT1
    Official Full Name
    Got1p
    Primary source
    SGD:S000004906
    Locus tag
    YMR292W
    See related
    AllianceGenome:SGD:S000004906; FungiDB:YMR292W; VEuPathDB:YMR292W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in endoplasmic reticulum to Golgi vesicle-mediated transport and retrograde transport, endosome to Golgi. Located in COPII-coated ER to Golgi transport vesicle; Golgi apparatus; and endoplasmic reticulum. Orthologous to human GOLT1A (golgi transport 1A) and GOLT1B (golgi transport 1B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GOT1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    2
    Sequence:
    Chromosome: XIII; NC_001145.3 (854795..855293)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene ATP-dependent RNA helicase HAS1 Neighboring gene protein kinase TDA1 Neighboring gene glutamyl-tRNA(Gln) amidotransferase subunit HER2 Neighboring gene Jnm1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multicopy suppressor analysis of thermosensitive YIP1 alleles implicates GOT1 in transport from the ER. Lorente-Rodríguez A, et al. J Cell Sci, 2009 May 15. PMID 19383723, Free PMC Article
    2. Widespread impact of nonsense-mediated mRNA decay on the yeast intronome. Sayani S, et al. Mol Cell, 2008 Aug 8. PMID 18691968, Free PMC Article
    3. Got1p and Sft2p: membrane proteins involved in traffic to the Golgi complex. Conchon S, et al. EMBO J, 1999 Jul 15. PMID 10406798, Free PMC Article
    4. The pre-mRNA retention and splicing complex controls tRNA maturation by promoting TAN1 expression. Zhou Y, et al. Nucleic Acids Res, 2013 Jun. PMID 23605039, Free PMC Article
    5. Sequential RNA degradation pathways provide a fail-safe mechanism to limit the accumulation of unspliced transcripts in Saccharomyces cerevisiae. Sayani S, et al. RNA, 2012 Aug. PMID 22753783, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in COPII-coated ER to Golgi transport vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi cis cisterna IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi cis cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Got1p
    NP_014020.1
    • Homodimeric protein that is packaged into COPII vesicles; cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      854795..855293
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182800.1 → NP_014020.1  TPA: Got1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014020.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0B9, Q03554
      UniProtKB/TrEMBL
      A6ZN08, B3LMI0, C7GTK7, C8ZFG0, G2WL01, N1P0R0
      Conserved Domains (1) summary
      COG5120
      Location:1 → 138
      GOT1; Membrane protein involved in Golgi transport [Intracellular trafficking and secretion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03554.1

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