U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    DIA4 putative serine--tRNA ligase DIA4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856402, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    DIA4
    Official Full Name
    putative serine--tRNA ligase DIA4
    Primary source
    SGD:S000001053
    Locus tag
    YHR011W
    See related
    AllianceGenome:SGD:S000001053; FungiDB:YHR011W; VEuPathDB:YHR011W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables serine-tRNA ligase activity. Involved in mitochondrial seryl-tRNA aminoacylation. Located in mitochondrion. Orthologous to human SARS2 (seryl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See DIA4 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (127780..129120)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Tda3p Neighboring gene ribosomal 60S subunit protein L27A Neighboring gene retromer subunit VPS29 Neighboring gene peptide alpha-N-acetyltransferase complex A subunit ARD1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Maize seryl-tRNA synthetase: specificity of substrate recognition by the organellar enzyme. Rokov-Plavec J, et al. Arch Biochem Biophys, 2002 Jan 1. PMID 11747308
    2. Seryl transfer ribonucleic acid synthetase from bakers' yeast. 3. The seryladenylate-enzyme complex and its interaction with transfer ribonucleic acids. Bluestein HG, et al. J Biol Chem, 1968 Sep 25. PMID 4879089
    3. Characterization and tRNA recognition of mammalian mitochondrial seryl-tRNA synthetase. Yokogawa T, et al. J Biol Chem, 2000 Jun 30. PMID 10764807
    4. Protein substrates of the arginine methyltransferase Hmt1 identified by proteome arrays. Low JK, et al. Proteomics, 2016 Feb. PMID 26572822
    5. Functional discovery via a compendium of expression profiles. Hughes TR, et al. Cell, 2000 Jul 7. PMID 10929718

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity, acting on a tRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-tRNA ligase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial seryl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial seryl-tRNA aminoacylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in seryl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    putative serine--tRNA ligase DIA4
    NP_011875.1
    • Probable mitochondrial seryl-tRNA synthetase; mutant displays increased invasive and pseudohyphal growth

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      127780..129120
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179141.1 → NP_011875.1  TPA: putative serine--tRNA ligase DIA4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011875.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKV6, P38705
      UniProtKB/TrEMBL
      A6ZSR5, B3LSD2, B5VJT6, C7GMQ0, C8ZA78, G2WF79, N1P2Q8
      Conserved Domains (1) summary
      TIGR00414
      Location:1 → 440
      serS; seryl-tRNA synthetase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38705.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools