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    COX10 protoheme IX farnesyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855931, updated on 9-Dec-2024

    Summary

    Official Symbol
    COX10
    Official Full Name
    protoheme IX farnesyltransferase
    Primary source
    SGD:S000006093
    Locus tag
    YPL172C
    See related
    AllianceGenome:SGD:S000006093; FungiDB:YPL172C; VEuPathDB:YPL172C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable protoheme IX farnesyltransferase activity. Involved in heme A biosynthetic process. Located in mitochondrion. Used to study cytochrome-c oxidase deficiency disease. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease and mitochondrial complex IV deficiency nuclear type 3. Orthologous to human COX10 (cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See COX10 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (224353..225741, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Nip100p Neighboring gene mitochondrial 54S ribosomal protein YmL40 Neighboring gene NADPH dehydrogenase Neighboring gene Dap1p

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protoheme IX farnesyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protoheme IX farnesyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protoheme IX farnesyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in heme A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in heme A biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heme O biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in heme biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protoheme IX farnesyltransferase
    NP_015153.1
    • Heme A:farnesyltransferase; catalyzes first step in conversion of protoheme to heme A prosthetic group required for cytochrome c oxidase activity; human ortholog COX10 can complement yeast cox10 null mutant; human ortholog COX10 is associated with mitochondrial disorders

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      224353..225741 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183986.1NP_015153.1  TPA: protoheme IX farnesyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015153.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3J6, P21592
      UniProtKB/TrEMBL
      B3LKQ6, B5VSZ9, C7GJC3
      Conserved Domains (1) summary
      TIGR01473
      Location:147442
      cyoE_ctaB; protoheme IX farnesyltransferase