MSN2 stress-responsive transcriptional activator MSN2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MSN2
Official Full Name: stress-responsive transcriptional activator MSN2
Primary source: SGD:S000004640
Locus tag: YMR037C
See related: AllianceGenome:SGD:S000004640; FungiDB:YMR037C; VEuPathDB:YMR037C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cellular response to caloric restriction; cellular response to ethanol; and cellular response to pH. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MSN2 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (344403..346517, complement)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of the transcription factors Hsf1, Msn2 and Msn4 in yeast uncovers transcriptional reprogramming in response to proteotoxic stress.
Title: Deletion of the transcription factors Hsf1, Msn2 and Msn4 in yeast uncovers transcriptional reprogramming in response to proteotoxic stress.
Intrinsically disordered regions of the Msn2 transcription factor encode multiple functions using interwoven sequence grammars.
Title: Intrinsically disordered regions of the Msn2 transcription factor encode multiple functions using interwoven sequence grammars.
Yeast transcription factor Msn2 binds to G4 DNA.
Title: Yeast transcription factor Msn2 binds to G4 DNA.
The molecular grammar of protein disorder guiding genome-binding locations.
Title: The molecular grammar of protein disorder guiding genome-binding locations.
Msn2/4 transcription factors positively regulate expression of Atg39 ER-phagy receptor.
Title: Msn2/4 transcription factors positively regulate expression of Atg39 ER-phagy receptor.
The InsP7 phosphatase Siw14 regulates inositol pyrophosphate levels to control localization of the general stress response transcription factor Msn2.
Title: The InsP(7) phosphatase Siw14 regulates inositol pyrophosphate levels to control localization of the general stress response transcription factor Msn2.
Intrinsically Disordered Regions Direct Transcription Factor In Vivo Binding Specificity.
Title: Intrinsically Disordered Regions Direct Transcription Factor In Vivo Binding Specificity.
Investigated the role of serine residue substitution at position 625 of Saccharomyces cerevisiae stress-responsive transcriptional activator MSN2 (msn2p).
Title: Ser625 of msn2 transcription factor is indispensable for ethanol tolerance and alcoholic fermentation process.
An excess level of Msn2 impairs endocytic degradation of Gnp1 through dysfunction of Ubp6 and other deubiquitinating enzymes.
Title: Effect of the deubiquitination enzyme gene UBP6 on the stress-responsive transcription factor Msn2-mediated control of the amino acid permease Gnp1 in yeast.
This work attempts to reveal the significance of specific serine residues of Msn2/4p, as possible targets of PKA, through substitution of these serine residues with alanine.
Title: Specific serine residues of Msn2/4 are responsible for regulation of alcohol fermentation rates and ethanol resistance.

Submit: New GeneRIF Correction See all GeneRIFs (47)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular hypotonic response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to acidic pH	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to acidic pH	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to alkaline pH	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to amino acid starvation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to arsenic-containing substance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to caloric restriction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to cold	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to ethanol	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to freezing	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to glucose starvation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to heat	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hydrogen peroxide	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to hydrogen peroxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hydrostatic pressure	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to nitrogen starvation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to nitrosative stress	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to salt	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to zinc ion starvation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chromatin remodeling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to starvation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: stress-responsive transcriptional activator MSN2

NP_013751.1

Stress-responsive transcriptional activator; activated in stochastic pulses of nuclear localization in response to various stress conditions; binds DNA at stress response elements of responsive genes; light sensing pathway component that accumulates in the nucleus in response to blue light; relative distribution to nucleus increases upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

344403..346517 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182534.1 → NP_013751.1 TPA: stress-responsive transcriptional activator MSN2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013751.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZL2, P33748

UniProtKB/TrEMBL

B5VPG7, C7GL82, C8ZEP4, N1NX71

Conserved Domains (5) summary

COG5048
Location:127 → 594

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:649 → 670

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:676 → 698

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:661 → 687

zf-H2C2_2; Zinc-finger double domain

pfam13894
Location:647 → 670

zf-C2H2_4; C2H2-type zinc finger