PMT5 putative dolichyl-phosphate-mannose-protein mannosyltransferase PMT5 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PMT5
Official Full Name: putative dolichyl-phosphate-mannose-protein mannosyltransferase PMT5
Primary source: SGD:S000002251
Locus tag: YDL093W
See related: AllianceGenome:SGD:S000002251; FungiDB:YDL093W; VEuPathDB:YDL093W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable dolichyl-phosphate-mannose-protein mannosyltransferase activity. Predicted to be involved in protein O-linked mannosylation. Located in endoplasmic reticulum. Part of dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt2p dimer complex and dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt3p dimer complex. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PMT5 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (289909..292140)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables mannosyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein O-linked glycosylation	IEA Inferred from Electronic Annotation more info
involved_in protein O-linked mannosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein O-linked mannosylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt2p dimer complex	IDA Inferred from Direct Assay more info	PubMed
part_of dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt3p dimer complex	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	HDA more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative dolichyl-phosphate-mannose-protein mannosyltransferase PMT5

NP_010190.1

EC 2.4.1.109

Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

289909..292140

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180152.1 → NP_010190.1 TPA: putative dolichyl-phosphate-mannose-protein mannosyltransferase PMT5 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010190.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRQ5, P52867, Q92181

UniProtKB/TrEMBL

A6ZXN4, G2WC69

Conserved Domains (1) summary

COG1928
Location:22 → 729

PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]