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    SAM2 methionine adenosyltransferase SAM2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852113, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SAM2
    Official Full Name
    methionine adenosyltransferase SAM2
    Primary source
    SGD:S000002910
    Locus tag
    YDR502C
    See related
    AllianceGenome:SGD:S000002910; FungiDB:YDR502C; VEuPathDB:YDR502C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ETH2
    Summary
    Enables methionine adenosyltransferase activity. Involved in S-adenosylmethionine biosynthetic process and methionine metabolic process. Located in cytoplasmic stress granule. Human ortholog(s) of this gene implicated in hypermethioninemia and lung cancer. Orthologous to several human genes including MAT1A (methionine adenosyltransferase 1A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SAM2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1453310..1454464, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L37B Neighboring gene Plm2p Neighboring gene phosphatidate phosphatase LPP1 Neighboring gene Spg3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. tRNAs undermethylation in a met-regulatory mutant of Saccharomyces cerevisiae. Fesneau C, et al. Biochimie, 1975. PMID 1096967
    2. Changes in SAM2 expression affect lactic acid tolerance and lactic acid production in Saccharomyces cerevisiae. Dato L, et al. Microb Cell Fact, 2014 Oct 30. PMID 25359316, Free PMC Article
    3. Biosynthesis of methionine and its control in wild type and regulatory mutants of Saccharomyces cerevisiae. Antoniewski J, et al. Biochimie, 1973 May. PMID 4585174
    4. Expression of secreted His-tagged S-adenosylmethionine synthetase in the methylotrophic yeast Pichia pastoris and its characterization, one-step purification, and immobilization. Luo Y, et al. Biotechnol Prog, 2008 Jan-Feb. PMID 18078345
    5. S-adenosyl methionine requiring mutants in Saccharomyces cerevisiae: evidences for the existence of two methionine adenosyl transferases. Cherest H, et al. Mol Gen Genet, 1978 Jul 11. PMID 355845

    See all (98) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SAM1 and SAM2 have different effects on genome stability through distinctive effects on gene expression and AdoMet levels.
      Title: Mutations in the S-Adenosylmethionine Synthetase Genes SAM1 and SAM2 Differentially Affect Genome Stability in Saccharomyces cerevisiae.
    2. Data showed that co-expression of MET6 and SAM2 improved intracellular methionine availability and redirected the methionine to S-adenosyl-L-methionine biosynthesis.
      Title: Improving methionine and ATP availability by MET6 and SAM2 co-expression combined with sodium citrate feeding enhanced SAM accumulation in Saccharomyces cerevisiae.
    3. modulation of SAM2 can have different outcomes, from clear effects to no significant phenotypic responses, upon lactic acid stress in different genetic backgrounds
      Title: Changes in SAM2 expression affect lactic acid tolerance and lactic acid production in Saccharomyces cerevisiae.
    4. SAM2 was successfully produced at high level by the recombinant methylotrophic yeast Pichia pastoris, and the secreted His6-tagged SAM synthetase was purified in a single chromatography step with a yield of approximately 82% for the total activity.
      Title: Expression of secreted His-tagged S-adenosylmethionine synthetase in the methylotrophic yeast Pichia pastoris and its characterization, one-step purification, and immobilization.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methionine adenosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methionine adenosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methionine adenosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in S-adenosylmethionine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in S-adenosylmethionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in S-adenosylmethionine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in methionine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic stress granule HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    methionine adenosyltransferase SAM2
    NP_010790.3
    • S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; comparative analysis suggests that a mitochondrially targeted form may result from translation starting at a non-canonical codon upstream of the annotated start codon

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1453310..1454464 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180810.3 → NP_010790.3  TPA: methionine adenosyltransferase SAM2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010790.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTC4, E9P927, P19358
      UniProtKB/TrEMBL
      A6ZZ91, B3LFG5, B5VH29, C7GKT8, C8Z659, G2WBN0, N1P7G8, T2A536
      Conserved Domains (1) summary
      cd18079
      Location:8 → 380
      S-AdoMet_synt; S-adenosylmethionine synthetase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P19358.3

    Gene LinkOut

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