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    VPS52 Vps52p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852095, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VPS52
    Official Full Name
    Vps52p
    Primary source
    SGD:S000002892
    Locus tag
    YDR484W
    See related
    AllianceGenome:SGD:S000002892; FungiDB:YDR484W; VEuPathDB:YDR484W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SAC2
    Summary
    Predicted to enable syntaxin binding activity. Involved in several processes, including Golgi to vacuole transport; intracellular sphingolipid homeostasis; and retrograde transport, endosome to Golgi. Located in Golgi apparatus. Part of GARP complex. Orthologous to human VPS52 (VPS52 subunit of GARP complex). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See VPS52 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1422763..1424688)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene U2-type spliceosomal complex subunit CWC21 Neighboring gene alpha-1,2-mannosyltransferase KRE2 Neighboring gene Vps72p Neighboring gene Vps60p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nucleotide sequence of the SAC2 gene of Saccharomyces cerevisiae. Kölling R, et al. Yeast, 1994 Sep. PMID 7754710
    2. Genomic approach to identification of mutations affecting caspofungin susceptibility in Saccharomyces cerevisiae. Markovich S, et al. Antimicrob Agents Chemother, 2004 Oct. PMID 15388447, Free PMC Article
    3. Suppressors of yeast actin mutations. Novick P, et al. Genetics, 1989 Apr. PMID 2656401, Free PMC Article
    4. Domains within the GARP subunit Vps54 confer separate functions in complex assembly and early endosome recognition. Quenneville NR, et al. Mol Biol Cell, 2006 Apr. PMID 16452629, Free PMC Article
    5. Atg9 sorting from mitochondria is impaired in early secretion and VFT-complex mutants in Saccharomyces cerevisiae. Reggiori F, et al. J Cell Sci, 2006 Jul 15. PMID 16787937, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to vacuole transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to vacuole transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actin filament-based process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular sphingolipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of GARP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GARP complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Vps52p
    NP_010772.1
    • Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi, and for mitosis after DNA damage induced checkpoint arrest; involved in localization of actin and chitin; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1422763..1424688
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180792.1 → NP_010772.1  TPA: Vps52p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010772.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTA7, P39904, Q03379
      UniProtKB/TrEMBL
      A6ZZ73, B3LFI2, B5VH11, C8Z642, G2WBL3, N1P7E3
      Conserved Domains (1) summary
      cl19950
      Location:47 → 607
      Sec3_C; Exocyst complex component Sec3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39904.2

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