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    ECM2 Ecm2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852357, updated on 27-Dec-2024

    Summary

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    Official Symbol
    ECM2
    Official Full Name
    Ecm2p
    Primary source
    SGD:S000000269
    Locus tag
    YBR065C
    See related
    AllianceGenome:SGD:S000000269; FungiDB:YBR065C; VEuPathDB:YBR065C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SLT11
    Summary
    Enables U6 snRNA binding activity. Involved in mRNA splicing, via spliceosome. Is active in nucleus. Orthologous to human RBM22 (RNA binding motif protein 22). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ECM2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (368584..369678, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Cnm1p Neighboring gene Nrg2p Neighboring gene putative lipase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Splicing factor slt11p and its involvement in formation of U2/U6 helix II in activation of the yeast spliceosome. Xu D, et al. Mol Cell Biol, 2001 Feb. PMID 11158289, Free PMC Article
    2. Structural mechanism of ergosterol regulation by fungal sterol transcription factor Upc2. Yang H, et al. Nat Commun, 2015 Feb 6. PMID 25655993
    3. Saccharomyces cerevisiae Ecm2 Modulates the Catalytic Steps of pre-mRNA Splicing. van der Feltz C, et al. RNA, 2021 Feb 5. PMID 33547186, Free PMC Article
    4. Synthetic lethality of yeast slt mutations with U2 small nuclear RNA mutations suggests functional interactions between U2 and U5 snRNPs that are important for both steps of pre-mRNA splicing. Xu D, et al. Mol Cell Biol, 1998 Apr. PMID 9528778, Free PMC Article
    5. The Spliceosome: A Protein-Directed Metalloribozyme. Shi Y. J Mol Biol, 2017 Aug 18. PMID 28733144

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables U6 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables U6 snRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pre-mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Prp19 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type catalytic step 1 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ecm2p
    NP_009621.3
    • Pre-mRNA splicing factor; facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      368584..369678 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178413.3 → NP_009621.3  TPA: Ecm2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009621.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ64, P38241, P89497
      UniProtKB/TrEMBL
      A6ZL09, B3LN84, C7GQI0, G2W970, N1PAS0
      Conserved Domains (1) summary
      cd12265
      Location:201 → 295
      RRM_SLT11; RNA recognition motif (RRM) found in pre-mRNA-splicing factor SLT11 and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38241.1

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