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    RCM1 rRNA (cytosine-C5-)-methyltransferase RCM1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855709, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RCM1
    Official Full Name
    rRNA (cytosine-C5-)-methyltransferase RCM1
    Primary source
    SGD:S000004967
    Locus tag
    YNL022C
    See related
    AllianceGenome:SGD:S000004967; FungiDB:YNL022C; VEuPathDB:YNL022C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables rRNA (cytosine-C5-)-methyltransferase activity. Involved in rRNA base methylation. Located in nucleolus. Orthologous to several human genes including NSUN5 (NOP2/Sun RNA methyltransferase 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RCM1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (591427..592899, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene putative protein-lysine N-methyltransferase Neighboring gene Fap1p Neighboring gene histone deacetylase HDA1 Neighboring gene serine/threonine protein kinase ARK1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel methyltransferase required for the formation of the hypermodified nucleoside wybutosine in eucaryotic tRNA. Kalhor HR, et al. Biochem Biophys Res Commun, 2005 Aug 26. PMID 16005430
    2. A cluster of methylations in the domain IV of 25S rRNA is required for ribosome stability. Gigova A, et al. RNA, 2014 Oct. PMID 25125595, Free PMC Article
    3. Eukaryotic rRNA Modification by Yeast 5-Methylcytosine-Methyltransferases and Human Proliferation-Associated Antigen p120. Bourgeois G, et al. PLoS One, 2015. PMID 26196125, Free PMC Article
    4. Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan. Schosserer M, et al. Nat Commun, 2015 Jan 30. PMID 25635753, Free PMC Article
    5. Yeast Nop2 and Rcm1 methylate C2870 and C2278 of the 25S rRNA, respectively. Sharma S, et al. Nucleic Acids Res, 2013 Oct. PMID 23913415, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rcm1 catalyzes methylation of m5C2278 of 25S rRNA in vivo.
      Title: Yeast Nop2 and Rcm1 methylate C2870 and C2278 of the 25S rRNA, respectively.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA (cytosine-C5-)-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables rRNA (cytosine-C5-)-methyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables rRNA (cytosine-C5-)-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA base methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA base methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in rRNA base methylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in rRNA base methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rRNA (cytosine-C5-)-methyltransferase RCM1
    NP_014376.3
    • rRNA m5C methyltransferase; methylates cytosine at position 2278 of 25S rRNA while Nop2p methylates cytosine at position 2870; contains seven beta-strand methyltransferase motif; localized to the nucleolus; interacts with Trm112p; homolog of NSUN5A, a human gene which is deleted in Williams-Beuren Syndrome

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      591427..592899 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182861.3 → NP_014376.3  TPA: rRNA (cytosine-C5-)-methyltransferase RCM1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014376.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1F7, P53972
      UniProtKB/TrEMBL
      A6ZS48, B3LNP3, B5VR15, C7GWN9, C8ZFJ8, G2WM73, N1NXN1
      Conserved Domains (1) summary
      COG0144
      Location:98 → 489
      RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53972.1

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