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    CTK3 Ctk3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854928, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CTK3
    Official Full Name
    Ctk3p
    Primary source
    SGD:S000004580
    Locus tag
    YML112W
    See related
    AllianceGenome:SGD:S000004580; FungiDB:YML112W; VEuPathDB:YML112W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in positive regulation of DNA-templated transcription, elongation; positive regulation of transcription by RNA polymerase I; and positive regulation of translational fidelity. Located in nucleolus and nucleoplasm. Part of CTDK-1 complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CTK3 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (45063..45953)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Taf8p Neighboring gene Dat1p Neighboring gene ubiquitin-ubiquitin ligase BUL2 Neighboring gene 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression, purification and crystallization of the complex of RNA polymerase II carboxyl-terminal repeat domain kinase subunits CTK2-CTK3 from Saccharomyces cerevisiae. Zhu W, et al. Protein Expr Purif, 2019 Feb. PMID 30240633
    2. The yeast carboxyl-terminal repeat domain kinase CTDK-I is a divergent cyclin-cyclin-dependent kinase complex. Sterner DE, et al. Mol Cell Biol, 1995 Oct. PMID 7565723, Free PMC Article
    3. Modulation of RNA polymerase II elongation efficiency by C-terminal heptapeptide repeat domain kinase I. Lee JM, et al. J Biol Chem, 1997 Apr 25. PMID 9110987
    4. Genetics of transcriptional regulation in yeast: connections to the RNA polymerase II CTD. Carlson M. Annu Rev Cell Dev Biol, 1997. PMID 9442866
    5. Activation of the cyclin-dependent kinase CTDK-I requires the heterodimerization of two unstable subunits. Hautbergue G, et al. J Biol Chem, 2001 Mar 16. PMID 11118453

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structure and activation mechanism of the yeast RNA Pol II CTD kinase CTDK-1 complex.
      Title: Structure and activation mechanism of the yeast RNA Pol II CTD kinase CTDK-1 complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription, elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription, elongation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription, elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of translational fidelity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CTDK-1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CTDK-1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of CTDK-1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ctk3p
    NP_013595.1
    • Gamma subunit of C-terminal domain kinase I; CTDK-I phosphorylates RNA polymerase II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and also phosphorylates ribosomal protein Rps2p to increase translational fidelity; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      45063..45953
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182474.1 → NP_013595.1  TPA: Ctk3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013595.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0H2, P46963, Q6LBS6
      UniProtKB/TrEMBL
      A6ZLV2, B5VP19, N1NYQ0
      Conserved Domains (1) summary
      pfam12350
      Location:225 → 284
      CTK3_C; CTD kinase subunit gamma CTK3 C-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46963.2

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