Ccdc103 coiled-coil domain containing 103 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccdc103provided by MGI
Official Full Name: coiled-coil domain containing 103provided by MGI
Primary source: MGI:MGI:1920543
See related: Ensembl:ENSMUSG00000020930 AllianceGenome:MGI:1920543
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1700039D13Rik
Summary: Predicted to enable protein homodimerization activity. Predicted to be involved in axonemal dynein complex assembly; determination of left/right symmetry; and epithelial cilium movement involved in extracellular fluid movement. Predicted to be located in motile cilium. Predicted to be part of outer dynein arm. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 17. Orthologous to human DNAAF19 (dynein axonemal assembly factor 19). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in testis adult (RPKM 8.7), cortex adult (RPKM 0.7) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E1; 11 66.48 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (102772050..102776042)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (102881224..102885216)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in axonemal dynein complex assembly	ISO Inferred from Sequence Orthology more info
involved_in cilium movement	IEA Inferred from Electronic Annotation more info
involved_in cilium movement	ISO Inferred from Sequence Orthology more info
involved_in determination of digestive tract left/right asymmetry	IEA Inferred from Electronic Annotation more info
involved_in determination of digestive tract left/right asymmetry	ISO Inferred from Sequence Orthology more info
involved_in determination of left/right symmetry	IBA Inferred from Biological aspect of Ancestor more info
involved_in epithelial cilium movement involved in extracellular fluid movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in heart looping	IEA Inferred from Electronic Annotation more info
involved_in heart looping	ISO Inferred from Sequence Orthology more info
involved_in inner dynein arm assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in inner dynein arm assembly	IEA Inferred from Electronic Annotation more info
involved_in inner dynein arm assembly	ISO Inferred from Sequence Orthology more info
involved_in outer dynein arm assembly	IEA Inferred from Electronic Annotation more info
involved_in outer dynein arm assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in motile cilium	IEA Inferred from Electronic Annotation more info
part_of outer dynein arm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: coiled-coil domain-containing protein 103

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001364757.1 → NP_001351686.1 coiled-coil domain-containing protein 103 isoform 2

Status: VALIDATED

Source sequence(s)

AL731670

Conserved Domains (1) summary

pfam13877
Location:30 → 118

RPAP3_C; Potential Monad-binding region of RPAP3
NM_028492.3 → NP_082768.1 coiled-coil domain-containing protein 103 isoform 1

See identical proteins and their annotated locations for NP_082768.1

Status: VALIDATED

Source sequence(s)

AI836178, AK032002, AL731670

Consensus CDS

CCDS25506.1

UniProtKB/Swiss-Prot

A2AH86, Q9D9P2

Related

ENSMUSP00000021307.4, ENSMUST00000021307.10

Conserved Domains (2) summary

pfam13877
Location:98 → 188

RPAP3_C; Potential Monad-binding region of RPAP3

pfam15867
Location:7 → 74

Dynein_attach_N; Dynein attachment factor N-terminus