Fam3d FAM3 metabolism regulating signaling molecule D [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fam3dprovided by MGI
Official Full Name: FAM3 metabolism regulating signaling molecule Dprovided by MGI
Primary source: MGI:MGI:1201784
See related: Ensembl:ENSMUSG00000021749 AllianceGenome:MGI:1201784
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EF-7; Oit1; 2310076N21Rik
Summary: Predicted to enable carbohydrate binding activity. Acts upstream of or within several processes, including neutrophil homeostasis; neutrophil migration; and positive regulation of macrophage antigen processing and presentation. Located in extracellular space. Is expressed in embryo; esophagus; olfactory epithelium; rectum; and testis. Orthologous to human FAM3D (FAM3 metabolism regulating signaling molecule D). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in colon adult (RPKM 202.8), large intestine adult (RPKM 30.6) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 A1; 14 4.83 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (14091010..14120836)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (8348937..8378763, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hepatocyte-secreted FAM3D ameliorates hepatic steatosis by activating FPR1-hnRNP U-GR-SCAD pathway to enhance lipid oxidation.
Title: Hepatocyte-secreted FAM3D ameliorates hepatic steatosis by activating FPR1-hnRNP U-GR-SCAD pathway to enhance lipid oxidation.
FAM3D: A gut secreted protein and its potential in the regulation of glucose metabolism.
Title: FAM3D: A gut secreted protein and its potential in the regulation of glucose metabolism.
Targeting cytokine-like protein FAM3D lowers blood pressure in hypertension.
Title: Targeting cytokine-like protein FAM3D lowers blood pressure in hypertension.
FAM3D, as a dual agonist of FPR1 and FPR2, induced Mac-1-mediated neutrophil recruitment and aggravated abdominal aortic aneurysm development through FPR-related Gi protein and beta-arrestin signaling.
Title: Deficiency of FAM3D (Family With Sequence Similarity 3, Member D), A Novel Chemokine, Attenuates Neutrophil Recruitment and Ameliorates Abdominal Aortic Aneurysm Development.
Fam3D is a gut-derived protein that is expressed and secreted in a nutritional status-dependent manner
Title: Oit1/Fam3D, a gut-secreted protein displaying nutritional status-dependent regulation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within aorta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin secretion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within neutrophil homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neutrophil migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of macrophage antigen processing and presentation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein FAM3D

Names: oncoprotein induced transcript 1; oncoprotein-induced protein 1; protein EF-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.