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    Dbi diazepam binding inhibitor [ Mus musculus (house mouse) ]

    Gene ID: 13167, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dbiprovided by MGI
    Official Full Name
    diazepam binding inhibitorprovided by MGI
    Primary source
    MGI:MGI:94865
    See related
    Ensembl:ENSMUSG00000026385 AllianceGenome:MGI:94865
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EP; Acbp; ACBD1; endozepine
    Summary
    Predicted to enable benzodiazepine receptor binding activity; identical protein binding activity; and long-chain fatty acyl-CoA binding activity. Acts upstream of or within several processes, including behavioral fear response; lateral ventricle development; and long-term synaptic potentiation. Located in mitochondrion. Is expressed in brain and early conceptus. Orthologous to human DBI (diazepam binding inhibitor, acyl-CoA binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E18 (RPKM 440.8), subcutaneous fat pad adult (RPKM 390.0) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dbi in Genome Data Viewer
    Location:
    1 E2.3; 1 52.65 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (120041010..120048826, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (120113280..120121096, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10029 Neighboring gene predicted gene, 41937 Neighboring gene predicted gene, 41938 Neighboring gene RIKEN cDNA 3110009E18 gene Neighboring gene STARR-positive B cell enhancer ABC_E4342 Neighboring gene STARR-positive B cell enhancer mm9_chr1:122050580-122050881 Neighboring gene STARR-positive B cell enhancer mm9_chr1:122093817-122094118 Neighboring gene STARR-seq mESC enhancer starr_02054 Neighboring gene STEAP family member 3 Neighboring gene STARR-seq mESC enhancer starr_02055 Neighboring gene predicted gene, 53581 Neighboring gene STARR-seq mESC enhancer starr_02056 Neighboring gene complement component 1, q subcomponent-like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables benzodiazepine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables fatty-acyl-CoA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fatty-acyl-CoA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables fatty-acyl-CoA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables long-chain fatty acyl-CoA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within behavioral fear response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within hair follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lateral ventricle development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within learning or memory IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within long-term synaptic potentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein lipidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylcholine acyl-chain remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of CoA-transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phospholipid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of synaptic transmission, GABAergic ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within skin development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within triglyceride metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in contractile muscle fiber ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in perinuclear endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-lipid complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    acyl-CoA-binding protein
    Names
    diazepam binding inhibitor, splice form 1b
    NP_001033088.1
    NP_031856.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037999.2NP_001033088.1  acyl-CoA-binding protein isoform 1

      See identical proteins and their annotated locations for NP_001033088.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC139867
      Consensus CDS
      CCDS15231.1
      UniProtKB/TrEMBL
      F6ZM12, Q4VWZ5
      Related
      ENSMUSP00000114705.3, ENSMUST00000151708.3
      Conserved Domains (1) summary
      cd00435
      Location:52134
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
    2. NM_007830.4NP_031856.1  acyl-CoA-binding protein isoform 2

      See identical proteins and their annotated locations for NP_031856.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) is shorter and has a different N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK020692, AV001592, CJ183794
      Consensus CDS
      CCDS15230.1
      UniProtKB/Swiss-Prot
      P31786
      UniProtKB/TrEMBL
      Q3ULV8, Q548W7
      Related
      ENSMUSP00000027634.7, ENSMUST00000027634.13
      Conserved Domains (1) summary
      cd00435
      Location:286
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      120041010..120048826 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)