Ormdl2 ORM1-like 2 (S. cerevisiae) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ormdl2provided by MGI
Official Full Name: ORM1-like 2 (S. cerevisiae)provided by MGI
Primary source: MGI:MGI:1914094
See related: Ensembl:ENSMUSG00000025353 AllianceGenome:MGI:1914094
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 0610012C09Rik
Summary: Predicted to be involved in ceramide metabolic process; intracellular sphingolipid homeostasis; and sphingolipid biosynthetic process. Predicted to act upstream of or within negative regulation of ceramide biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be part of serine palmitoyltransferase complex. Orthologous to human ORMDL2 (ORMDL sphingolipid biosynthesis regulator 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in large intestine adult (RPKM 24.4), genital fat pad adult (RPKM 19.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 77.16 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (128653771..128657498, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (128817902..128821629, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ORMDL2 Deficiency Potentiates the ORMDL3-Dependent Changes in Mast Cell Signaling.
Title: ORMDL2 Deficiency Potentiates the ORMDL3-Dependent Changes in Mast Cell Signaling.
we attempted to generate Ormdl triple knockouts mice by crossing Ormdl 1-/- 2 +/- 3 +/- mice, no viable Ormdl1/2/3 triple knockouts mice were identified at weaning.
Title: The Ormdl genes regulate the sphingolipid synthesis pathway to ensure proper myelination and neurologic function in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in ceramide metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ceramide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ceramide metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular sphingolipid homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of ceramide biosynthetic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in sphingolipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
part_of serine palmitoyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ORM1-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.