Gnpda1 glucosamine-6-phosphate deaminase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gnpda1provided by MGI
Official Full Name: glucosamine-6-phosphate deaminase 1provided by MGI
Primary source: MGI:MGI:1347054
See related: Ensembl:ENSMUSG00000052102 AllianceGenome:MGI:1347054
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gnp1; Gnpi; GNPDA; oscillin
Summary: Predicted to enable glucosamine-6-phosphate deaminase activity and identical protein binding activity. Predicted to be involved in UDP-N-acetylglucosamine biosynthetic process; amino sugar catabolic process; and generation of precursor metabolites and energy. Predicted to act upstream of or within fructose 6-phosphate metabolic process; fructose biosynthetic process; and glucosamine metabolic process. Located in cytoplasm. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human GNPDA1 (glucosamine-6-phosphate deaminase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in kidney adult (RPKM 62.3), placenta adult (RPKM 57.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B3; 18 20.23 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (38460588..38472052, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (38327537..38338993, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables glucosamine-6-phosphate deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucosamine-6-phosphate deaminase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables glucosamine-6-phosphate deaminase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables identical protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in N-acetylglucosamine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in N-acetylglucosamine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in N-acetylneuraminate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in UDP-N-acetylglucosamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in UDP-N-acetylglucosamine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in UDP-N-acetylglucosamine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within acrosome reaction	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within fructose 6-phosphate metabolic process	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within fructose biosynthetic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in generation of precursor metabolites and energy	ISO Inferred from Sequence Orthology more info
involved_in generation of precursor metabolites and energy	ISS Inferred from Sequence or Structural Similarity more info
involved_in glucosamine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucosamine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in glucosamine catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within glucosamine metabolic process	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: glucosamine-6-phosphate isomerase 1

Names: GNPDA 1; glcN6P deaminase 1; glucose-6-phosphate isomerase

NP_036067.2

EC 3.5.99.6

XP_036017048.1

EC 3.5.99.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011937.2 → NP_036067.2 glucosamine-6-phosphate isomerase 1

See identical proteins and their annotated locations for NP_036067.2

Status: VALIDATED

Source sequence(s)

AK167088, BY092839, BY443103, CJ048539

Consensus CDS

CCDS29201.1

UniProtKB/Swiss-Prot

O88958, Q91WJ4, Q9R188

UniProtKB/TrEMBL

Q6A0D9

Related

ENSMUSP00000069081.9, ENSMUST00000063814.15

Conserved Domains (1) summary

cl00339
Location:1 → 253

SugarP_isomerase; SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

38460588..38472052 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161155.1 → XP_036017048.1 glucosamine-6-phosphate isomerase 1 isoform X1

UniProtKB/TrEMBL

Q8BK00

Conserved Domains (1) summary

cl00339
Location:1 → 165

SugarP_isomerase; Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose ...