U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Tmem150b transmembrane protein 150B [ Mus musculus (house mouse) ]

    Gene ID: 330460, updated on 27-Nov-2024

    Summary

    Official Symbol
    Tmem150bprovided by MGI
    Official Full Name
    transmembrane protein 150Bprovided by MGI
    Primary source
    MGI:MGI:2679718
    See related
    Ensembl:ENSMUSG00000046456 AllianceGenome:MGI:2679718
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmem224; A630041N19
    Summary
    Predicted to be involved in autophagy. Predicted to be located in autophagosome membrane and endosome membrane. Predicted to be active in plasma membrane. Orthologous to human TMEM150B (transmembrane protein 150B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cortex adult (RPKM 24.1), frontal lobe adult (RPKM 20.5) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tmem150b in Genome Data Viewer
    Location:
    7 A1; 7 2.72 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4709831..4728250, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4706832..4725251, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 6, regulatory subunit 1 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:4605526-4605679 Neighboring gene STARR-positive B cell enhancer ABC_E3695 Neighboring gene HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 Neighboring gene STARR-positive B cell enhancer ABC_E2219 Neighboring gene BR serine/threonine kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E127 Neighboring gene predicted gene, 24537 Neighboring gene predicted gene, 42369

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Clone Names

    • MGC31268

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in autophagosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    modulator of macroautophagy TMEM150B
    Names
    transmembrane protein 224

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142792.1NP_001136264.1  modulator of macroautophagy TMEM150B isoform 1

      See identical proteins and their annotated locations for NP_001136264.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC161197
      Consensus CDS
      CCDS51975.1
      UniProtKB/Swiss-Prot
      Q8C9L9, Q8R218
      Related
      ENSMUSP00000083549.5, ENSMUST00000086363.5
      Conserved Domains (1) summary
      pfam10277
      Location:4205
      Frag1; Frag1/DRAM/Sfk1 family
    2. NM_177887.4NP_808555.1  modulator of macroautophagy TMEM150B isoform 2

      See identical proteins and their annotated locations for NP_808555.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 3' sequence, as compared to variant 1. The resulting isoform (2) has a shorter and different C-terminus, as compared to isoform 1.
      Source sequence(s)
      AC161197
      Consensus CDS
      CCDS20742.1
      UniProtKB/Swiss-Prot
      Q8R218
      Related
      ENSMUSP00000083550.5, ENSMUST00000086364.11
      Conserved Domains (1) summary
      pfam10277
      Location:4108
      Frag1; Frag1/DRAM/Sfk1 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      4709831..4728250 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)