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    Prmt9 protein arginine methyltransferase 9 [ Mus musculus (house mouse) ]

    Gene ID: 102182, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Prmt9provided by MGI
    Official Full Name
    protein arginine methyltransferase 9provided by MGI
    Primary source
    MGI:MGI:2142651
    See related
    Ensembl:ENSMUSG00000037134 AllianceGenome:MGI:2142651
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Prmt10
    Summary
    Predicted to enable histone methyltransferase activity and protein-arginine omega-N symmetric methyltransferase activity. Predicted to be involved in chromatin remodeling; mRNA processing; and regulation of DNA-templated transcription. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human PRMT9 (protein arginine methyltransferase 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.2), CNS E18 (RPKM 6.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Prmt9 in Genome Data Viewer
    Location:
    8 C1; 8 36.61 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (78276015..78307966)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (77549388..77581338)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 10 Neighboring gene predicted gene 45407 Neighboring gene STARR-seq mESC enhancer starr_21953 Neighboring gene STARR-seq mESC enhancer starr_21954 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:79946917-79947070 Neighboring gene RIKEN cDNA 0610038B21 gene Neighboring gene STARR-seq mESC enhancer starr_21957 Neighboring gene STARR-positive B cell enhancer ABC_E9317 Neighboring gene STARR-positive B cell enhancer ABC_E8249 Neighboring gene STARR-seq mESC enhancer starr_21958 Neighboring gene STARR-positive B cell enhancer ABC_E1761 Neighboring gene transmembrane protein 184C Neighboring gene predicted gene, 39200

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss-of-function mutation in PRMT9 causes abnormal synapse development by dysregulation of RNA alternative splicing. Shen L, et al. Nat Commun, 2024 Apr 1. PMID 38561334, Free PMC Article
    2. The protein arginine methyltransferase PRMT9 attenuates MAVS activation through arginine methylation. Bai X, et al. Nat Commun, 2022 Aug 26. PMID 36028484, Free PMC Article
    3. Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity. Dong H, et al. Nat Cancer, 2024 Apr. PMID 38413714, Free PMC Article
    4. Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo. Burton A, et al. Cell Rep, 2013 Nov 14. PMID 24183668
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss-of-function mutation in PRMT9 causes abnormal synapse development by dysregulation of RNA alternative splicing.
      Title: Loss-of-function mutation in PRMT9 causes abnormal synapse development by dysregulation of RNA alternative splicing.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone H2AQ104 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K37 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K56 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3R17 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3R2 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3R26 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3R8 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K12 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4R3 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone arginine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-arginine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-arginine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-arginine N-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-arginine omega-N symmetric methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-arginine omega-N symmetric methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein arginine N-methyltransferase 9
    Names
    protein arginine N-methyltransferase 10
    protein arginine methyltransferase 10 (putative)
    putative protein arginine N-methyltransferase 10
    putative protein arginine N-methyltransferase 9
    NP_001074709.1
    NP_001350394.1
    NP_001413523.1
    XP_036009600.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081240.4 → NP_001074709.1  protein arginine N-methyltransferase 9 isoform 1

      See identical proteins and their annotated locations for NP_001074709.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC109139, AC113049
      Consensus CDS
      CCDS40394.1
      UniProtKB/Swiss-Prot
      D3YU52, Q3U3W5, Q8BLF8, Q8BLG1
      UniProtKB/TrEMBL
      F8WIU7
      Related
      ENSMUSP00000050181.9, ENSMUST00000056237.15
      Conserved Domains (3) summary
      sd00006
      Location:68 → 95
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:68 → 132
      TPR_11; TPR repeat
      cl17173
      Location:148 → 303
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. NM_001363465.2 → NP_001350394.1  protein arginine N-methyltransferase 9 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC109139, AC113049

    3. NM_001426594.1 → NP_001413523.1  protein arginine N-methyltransferase 9 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC109139, AC113049

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      78276015..78307966
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153707.1 → XP_036009600.1  protein arginine N-methyltransferase 9 isoform X1

    RNA

    1. XR_004934743.1 RNA Sequence

      Related
      ENSMUST00000210040.2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178903.2: Suppressed sequence

      Description
      NM_178903.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U3W5.2 GenPept UniProtKB/Swiss-Prot:Q3U3W5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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