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    IGHA1 immunoglobulin heavy constant alpha 1 [ Homo sapiens (human) ]

    Gene ID: 3493, updated on 10-Dec-2024

    Summary

    Official Symbol
    IGHA1provided by HGNC
    Official Full Name
    immunoglobulin heavy constant alpha 1provided by HGNC
    Primary source
    HGNC:HGNC:5478
    See related
    Ensembl:ENSG00000211895 IMGT/GENE-DB:IGHA1; MIM:146900; AllianceGenome:HGNC:5478
    Gene type
    other
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IgA1
    Summary
    Contributes to immunoglobulin receptor binding activity. Involved in glomerular filtration and positive regulation of respiratory burst. Located in extracellular space. Part of monomeric IgA immunoglobulin complex and secretory dimeric IgA immunoglobulin complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See IGHA1 in Genome Data Viewer
    Location:
    14q32.33
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (105707168..105708664, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (99979057..99980553, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (106173505..106175001, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene immunoglobulin heavy locus Neighboring gene immunoglobulin heavy constant gamma 2 (G2m marker) Neighboring gene ETS transcription factor ELK2A, pseudogene Neighboring gene immunoglobulin heavy constant gamma P (non-functional) Neighboring gene immunoglobulin heavy constant epsilon P1 (pseudogene) Neighboring gene immunoglobulin heavy constant gamma 1 (G1m marker)

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Other Names

    • immunoglobulin alpha 1
    • immunoglobulin heavy chain constant region alpha 1

    Clone Names

    • FLJ14473, FLJ35065, FLJ35500, FLJ36402, FLJ39698, FLJ40001, FLJ41548, FLJ41552, FLJ41789, FLJ43248, FLJ43594, FLJ44293, FLJ46028, FLJ46621, FLJ46724, FLJ46811, FLJ46824, FLJ90170, MGC102857, AL928768.3

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables antigen binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    contributes_to immunoglobulin receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in B cell receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in adaptive immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in antibacterial humoral response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in antibacterial humoral response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in complement activation, classical pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glomerular filtration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of respiratory burst IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_001019.6 

      Range
      1171681..1173207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      105707168..105708664 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187600.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      174937..176433 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      99979057..99980553 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)