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    PEBP4 phosphatidylethanolamine binding protein 4 [ Homo sapiens (human) ]

    Gene ID: 157310, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PEBP4provided by HGNC
    Official Full Name
    phosphatidylethanolamine binding protein 4provided by HGNC
    Primary source
    HGNC:HGNC:28319
    See related
    Ensembl:ENSG00000134020 MIM:612473; AllianceGenome:HGNC:28319
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CORK1; CORK-1; PEBP-4; hPEBP4; PRO4408; GWTM1933; HEL-S-300
    Summary
    The phosphatidylethanolamine (PE)-binding proteins, including PEBP4, are an evolutionarily conserved family of proteins with pivotal biologic functions, such as lipid binding and inhibition of serine proteases (Wang et al., 2004 [PubMed 15302887]).[supplied by OMIM, Dec 2008]
    Expression
    Biased expression in lung (RPKM 23.8), heart (RPKM 14.9) and 5 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PEBP4 in Genome Data Viewer
    Location:
    8p21.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (22713251..22941077, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (22987819..23216048, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (22570764..22798590, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19009 Neighboring gene uncharacterized LOC105379321 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19010 Neighboring gene uncharacterized LOC107986926 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19011 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19012 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27087 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27088 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27089 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27090 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22572425-22573228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27092 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27093 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27094 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27095 Neighboring gene MPRA-validated peak6940 silencer Neighboring gene uncharacterized LOC124901908 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:22601507-22602706 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19013 Neighboring gene uncharacterized LOC107986925 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27096 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22634644-22635144 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22635145-22635645 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22640438-22641124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22641125-22641811 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22642499-22643184 Neighboring gene uncharacterized LOC105379325 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:22669609-22669787 Neighboring gene uncharacterized LOC124901906 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr8:22721642-22722218 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22722219-22722794 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19015 Neighboring gene uncharacterized LOC101929237 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27097 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22744265-22744765 Neighboring gene uncharacterized LOC124901907 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:22760306-22760493 Neighboring gene Sharpr-MPRA regulatory region 3596 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22769137-22769908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22769909-22770680 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22777059-22777987 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22809645-22810276 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22810277-22810907 Neighboring gene uncharacterized LOC107984124 Neighboring gene NANOG hESC enhancer GRCh37_chr8:22814761-22815262 Neighboring gene VISTA enhancer hs1927 Neighboring gene Rho related BTB domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27100 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22845205-22845961 Neighboring gene RNA, 7SL, cytoplasmic 303, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19017 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19018 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19019 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22861268-22861793 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22861794-22862318 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:22866186-22866771 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22871840-22872604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27102 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:22876025-22876192 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22876488-22877052 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22877053-22877615 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:22885758-22886258 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:22886259-22886759 Neighboring gene TNF receptor superfamily member 10b Neighboring gene Sharpr-MPRA regulatory region 6582 Neighboring gene TNFRSF10B antisense RNA 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:22921484-22922683 Neighboring gene TNFRSF10B 5' regulatory region

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Diagnostic value of phosphatidylethanolamine binding protein 4 levels in patients receiving nursing interventions for advanced chronic kidney disease. He P, et al. J Int Med Res, 2021 Mar. PMID 33752499, Free PMC Article
    2. Anti-apoptotic hPEBP4 silencing promotes TRAIL-induced apoptosis of human ovarian cancer cells by activating ERK and JNK pathways. Li P, et al. Int J Mol Med, 2006 Sep. PMID 16865237
    3. The expression of PEBP4 protein in lung squamous cell carcinoma. Yu GP, et al. Tumour Biol, 2011 Dec. PMID 21887552
    4. PEBP4 gene expression and its significance in invasion and metastasis of non-small cell lung cancer. Yu GP, et al. Tumour Biol, 2012 Feb. PMID 22076923
    5. Expression of PEBP4 protein correlates with the invasion and metastasis of colorectal cancer. Liu H, et al. Tumour Biol, 2012 Feb. PMID 22125029

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of phosphatidylethanolamine-binding protein 4 (PEBP4) associates with recurrence of meningiomas.
      Title: Overexpression of phosphatidylethanolamine-binding protein 4 (PEBP4) associates with recurrence of meningiomas.
    2. Diagnostic value of phosphatidylethanolamine binding protein 4 levels in patients receiving nursing interventions for advanced chronic kidney disease.
      Title: Diagnostic value of phosphatidylethanolamine binding protein 4 levels in patients receiving nursing interventions for advanced chronic kidney disease.
    3. PEBP4 colocalised with IgA and CD19.
      Title: Phosphatidylethanolamine binding protein-4 (PEBP4) is increased in IgA nephropathy and is associated with IgA-positive B-cells in affected kidneys.
    4. these results suggest that PEBP4 may promote tumorigenesis in non-small cell lung cancer by regulating cell proliferation and epithelial-to-mesenchymal transition via activation of the Shh signaling pathway.
      Title: Phosphatidylethanolamine-binding protein 4 promotes the epithelial-to-mesenchymal transition in non-small cell lung cancer cells by activating the sonic hedgehog signaling pathway.
    5. High PEBP4 expression is associated with glioma cell growth and invasiveness.
      Title: Knockdown of PEBP4 inhibits human glioma cell growth and invasive potential via ERK1/2 signaling pathway.
    6. PEBP4 was associated with the development and invasion of gastric cancer cells through activation of the PI3K/Akt signaling pathway
      Title: Role of the PEBP4 protein in the development and metastasis of gastric cancer.
    7. knockdown of PEBP4 inhibited hypoxia-induced epithelial-to-mesenchymal transition in prostate cancer cells.
      Title: PEBP4 silencing inhibits hypoxia-induced epithelial-to-mesenchymal transition in prostate cancer cells.
    8. this study suggested that PEBP4 might promote the progression of pancreatic ductal adenocarcinoma
      Title: PEBP4 promoted the growth and migration of cancer cells in pancreatic ductal adenocarcinoma.
    9. Increased expression of phosphatidylethanolamine-binding protein 4 strongly associates with gliomas grade.
      Title: Increased expression of phosphatidylethanolamine-binding protein 4 (PEBP4) strongly associates with human gliomas grade.
    10. PEBP4 is a secreted protein and has multiple functions, including a role in Akt phosphorylation.
      Title: Phosphatidylethanolamine binding protein 4 (PEBP4) is a secreted protein and has multiple functions.
    Submit: New GeneRIF Correction See all GeneRIFs (25)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association meta-analysis of preschool internalizing problems.
    EBI GWAS Catalog
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog
    Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC22776

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 

    General protein information

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    Preferred Names
    phosphatidylethanolamine-binding protein 4
    Names
    cousin-of-RKIP 1 protein
    epididymis secretory protein Li 300
    epididymis secretory sperm binding protein
    protein cousin-of-RKIP 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363233.2 → NP_001350162.1  phosphatidylethanolamine-binding protein 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC105046, AC134389, AY359109, AY730275
      Consensus CDS
      CCDS43724.1
      UniProtKB/Swiss-Prot
      Q5EVA1, Q8WW74, Q96S96
      UniProtKB/TrEMBL
      V9HW76
      Conserved Domains (1) summary
      cd00866
      Location:46 → 197
      PEBP_euk; PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes

    2. NM_144962.3 → NP_659399.2  phosphatidylethanolamine-binding protein 4 precursor

      See identical proteins and their annotated locations for NP_659399.2

      Status: VALIDATED

      Source sequence(s)
      AC037441, AC105046, AY037148, AY359109, BF853000
      Consensus CDS
      CCDS43724.1
      UniProtKB/Swiss-Prot
      Q5EVA1, Q8WW74, Q96S96
      UniProtKB/TrEMBL
      V9HW76
      Related
      ENSP00000256404.6, ENST00000256404.8
      Conserved Domains (1) summary
      cd00866
      Location:46 → 197
      PEBP_euk; PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      22713251..22941077 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017013103.2 → XP_016868592.1  phosphatidylethanolamine-binding protein 4 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      22987819..23216048 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359810.1 → XP_054215785.1  phosphatidylethanolamine-binding protein 4 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96S96.3 GenPept UniProtKB/Swiss-Prot:Q96S96

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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