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    LUCAT1 lung cancer associated transcript 1 [ Homo sapiens (human) ]

    Gene ID: 100505994, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LUCAT1provided by HGNC
    Official Full Name
    lung cancer associated transcript 1provided by HGNC
    Primary source
    HGNC:HGNC:48498
    See related
    Ensembl:ENSG00000248323 MIM:618190; AllianceGenome:HGNC:48498
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SCAL1; SCAT5
    Expression
    Biased expression in appendix (RPKM 2.5), bone marrow (RPKM 1.2) and 9 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See LUCAT1 in Genome Data Viewer
    Location:
    5q14.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (91302986..91314402, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (91786853..91798267, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (90598803..90610219, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986432 Neighboring gene uncharacterized LOC107986433 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22785 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:90575335-90576276 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:90576277-90577218 Neighboring gene RNA, U4 small nuclear 90, pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:90607093-90608292 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:90609644-90610843 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:90627976-90628476 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:90634700-90635294 Neighboring gene ribosomal protein S18 pseudogene 7 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16171 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16172 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:90679204-90679721 Neighboring gene ARRDC3 antisense RNA 1 Neighboring gene arrestin domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. LUCAT1 as an oncogene in tongue squamous cell carcinoma by targeting miR-375 expression. Zhang K, et al. J Cell Mol Med, 2021 May. PMID 33787082, Free PMC Article
    2. Long non‑coding RNA LUCAT1 contributes to cisplatin resistance by regulating the miR‑514a‑3p/ULK1 axis in human non‑small cell lung cancer. Shen Q, et al. Int J Oncol, 2020 Oct. PMID 32945379, Free PMC Article
    3. Identification of dysregulated lncRNAs profiling and metastasis-associated lncRNAs in colorectal cancer by genome-wide analysis. Chen Y, et al. Cancer Med, 2017 Oct. PMID 28857495, Free PMC Article
    4. Long non-coding RNA LUCAT1 is associated with poor prognosis in human non-small lung cancer and regulates cell proliferation via epigenetically repressing p21 and p57 expression. Sun Y, et al. Oncotarget, 2017 Apr 25. PMID 28423699, Free PMC Article
    5. LUCAT1 contributes to MYRF-dependent smooth muscle cell apoptosis and may facilitate aneurysm formation via the sequestration of miR-199a-5p. Xia Q, et al. Cell Biol Int, 2020 Mar. PMID 31769911

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long non-coding RNA lung cancer-associated transcript 1 regulates ferroptosis via microRNA-34a-5p-mediated GTP cyclohydrolase 1 downregulation in lung cancer cells.
      Title: Long non‑coding RNA lung cancer‑associated transcript 1 regulates ferroptosis via microRNA‑34a‑5p‑mediated GTP cyclohydrolase 1 downregulation in lung cancer cells.
    2. LUCAT1 inhibits ferroptosis in bladder cancer by regulating the mRNA stability of STAT3.
      Title: LUCAT1 inhibits ferroptosis in bladder cancer by regulating the mRNA stability of STAT3.
    3. The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2.
      Title: The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2.
    4. lncRNA LUCAT1/ELAVL1/LIN28B/SOX2 Positive Feedback Loop Promotes Cell Stemness in Triple-Negative Breast Cancer.
      Title: lncRNA LUCAT1/ELAVL1/LIN28B/SOX2 Positive Feedback Loop Promotes Cell Stemness in Triple-Negative Breast Cancer.
    5. LncRNA PVT1 is increased in renal cell carcinoma and affects viability and migration in vitro.
      Title: LncRNA PVT1 is increased in renal cell carcinoma and affects viability and migration in vitro.
    6. Knockdown of lncRNA LUCAT1 attenuates sepsisinduced myocardial cell injury by sponging miR-642a.
      Title: Knockdown of lncRNA LUCAT1 attenuates sepsis‑induced myocardial cell injury by sponging miR-642a.
    7. Expression of long non-coding RNA LUCAT1 in patients with chronic obstructive pulmonary disease and its potential functions in regulating cigarette smoke extract-induced 16HBE cell proliferation and apoptosis.
      Title: Expression of long non-coding RNA LUCAT1 in patients with chronic obstructive pulmonary disease and its potential functions in regulating cigarette smoke extract-induced 16HBE cell proliferation and apoptosis.
    8. Long non-coding RNA LUCAT1 inhibits myocardial oxidative stress and apoptosis after myocardial infarction via targeting microRNA-181a-5p.
      Title: Long non-coding RNA LUCAT1 inhibits myocardial oxidative stress and apoptosis after myocardial infarction via targeting microRNA-181a-5p.
    9. Concomitant and decoupled effects of cigarette smoke and SCAL1 upregulation on oncogenic phenotypes and ROS detoxification in lung adenocarcinoma cells.
      Title: Concomitant and decoupled effects of cigarette smoke and SCAL1 upregulation on oncogenic phenotypes and ROS detoxification in lung adenocarcinoma cells.
    10. Long Noncoding RNA LUCAT1 Promotes Multiple Myeloma Cell Growth by Regulating the TGF-beta Signaling Pathway.
      Title: Long Noncoding RNA LUCAT1 Promotes Multiple Myeloma Cell Growth by Regulating the TGF-β Signaling Pathway.
    Submit: New GeneRIF Correction See all GeneRIFs (44)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Other Names

    • S-phase cancer-associated transcript 7
    • lung cancer associated transcript 1 (non-protein coding)
    • smoke and cancer associated lncRNA 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_103548.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AC123595
      Related
      ENST00000511918.6

    2. NR_103549.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks three 3' exons and contains an alternate 3' exon, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AC123595
      Related
      ENST00000730091.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      91302986..91314402 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      91786853..91798267 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Research Materials