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    PRM1 protamine 1 [ Homo sapiens (human) ]

    Gene ID: 5619, updated on 9-Dec-2024

    Summary

    Official Symbol
    PRM1provided by HGNC
    Official Full Name
    protamine 1provided by HGNC
    Primary source
    HGNC:HGNC:9447
    See related
    Ensembl:ENSG00000175646 MIM:182880; AllianceGenome:HGNC:9447
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P1; CT94.1
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in chromosome organization and spermatogenesis. Predicted to act upstream of or within nucleus organization and spermatid development. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis (RPKM 2212.7) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PRM1 in Genome Data Viewer
    Location:
    16p13.13
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (11280841..11281330, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (11317056..11317545, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (11374698..11375187, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371082 Neighboring gene uncharacterized LOC124900380 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11379964-11380464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11380465-11380965 Neighboring gene protamine 2 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10430 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:11391651-11392334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10431 Neighboring gene microRNA 548h-2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genetic variants associated with disordered eating.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in chromosome condensation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromosome organization TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in sperm DNA condensation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    sperm protamine P1
    Names
    cancer/testis antigen family 94, member 1
    cysteine-rich protamine
    testicular tissue protein Li 91
    testis specific protamine 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002761.3NP_002752.1  sperm protamine P1

      See identical proteins and their annotated locations for NP_002752.1

      Status: VALIDATED

      Source sequence(s)
      AC009121, AY651260, CD360017
      Consensus CDS
      CCDS10547.1
      UniProtKB/Swiss-Prot
      P04553
      UniProtKB/TrEMBL
      Q3MN80
      Related
      ENSP00000310515.3, ENST00000312511.4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      11280841..11281330 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      11317056..11317545 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)