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    SEC14L5 SEC14 like lipid binding 5 [ Homo sapiens (human) ]

    Gene ID: 9717, updated on 9-Dec-2024

    Summary

    Official Symbol
    SEC14L5provided by HGNC
    Official Full Name
    SEC14 like lipid binding 5provided by HGNC
    Primary source
    HGNC:HGNC:29032
    See related
    Ensembl:ENSG00000103184 MIM:619412; AllianceGenome:HGNC:29032
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRELID4B
    Summary
    Predicted to be located in mitochondrial intermembrane space. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in brain (RPKM 6.8), heart (RPKM 1.4) and 3 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SEC14L5 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (4958330..5019157)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (4987819..5048658)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (5008331..5069158)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4945259-4946104 Neighboring gene uncharacterized LOC124903637 Neighboring gene periplakin Neighboring gene uncharacterized LOC105371064 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4968443-4968998 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4978324-4978894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7170 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4992871-4993384 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4993385-4993898 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4993899-4994412 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4997813-4998570 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:5008323-5008858 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:5019509-5020008 Neighboring gene Sharpr-MPRA regulatory region 439 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:5051228-5051419 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:5060637-5061160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:5061161-5061684 Neighboring gene Sharpr-MPRA regulatory region 11332 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:5078448-5079647 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:5083173-5083674 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10347 Neighboring gene NAGPA antisense RNA 1 Neighboring gene N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase Neighboring gene chromosome 16 open reading frame 89 Neighboring gene Sharpr-MPRA regulatory region 9075

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0420

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    SEC14-like protein 5
    Names
    SEC14-like 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014692.2NP_055507.1  SEC14-like protein 5

      See identical proteins and their annotated locations for NP_055507.1

      Status: VALIDATED

      Source sequence(s)
      AB007880, AC007011, AC026458
      Consensus CDS
      CCDS45403.1
      UniProtKB/Swiss-Prot
      O43304
      Related
      ENSP00000251170.6, ENST00000251170.12
      Conserved Domains (3) summary
      smart00516
      Location:306479
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      smart01100
      Location:243288
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      pfam04707
      Location:17173
      PRELI; PRELI-like family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      4958330..5019157
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024450497.2XP_024306265.1  SEC14-like protein 5 isoform X1

      UniProtKB/Swiss-Prot
      O43304
      Conserved Domains (3) summary
      smart00516
      Location:306479
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      smart01100
      Location:243288
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      pfam04707
      Location:17173
      PRELI; PRELI-like family
    2. XM_024450498.2XP_024306266.1  SEC14-like protein 5 isoform X1

      UniProtKB/Swiss-Prot
      O43304
      Conserved Domains (3) summary
      smart00516
      Location:306479
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      smart01100
      Location:243288
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      pfam04707
      Location:17173
      PRELI; PRELI-like family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      4987819..5048658
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314487.1XP_054170462.1  SEC14-like protein 5 isoform X1

      UniProtKB/Swiss-Prot
      O43304
    2. XM_054314486.1XP_054170461.1  SEC14-like protein 5 isoform X1

      UniProtKB/Swiss-Prot
      O43304