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    MIA2 MIA SH3 domain ER export factor 2 [ Homo sapiens (human) ]

    Gene ID: 4253, updated on 3-Dec-2024

    Summary

    Official Symbol
    MIA2provided by HGNC
    Official Full Name
    MIA SH3 domain ER export factor 2provided by HGNC
    Primary source
    HGNC:HGNC:18432
    See related
    Ensembl:ENSG00000150527 MIM:602132; AllianceGenome:HGNC:18432
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MEA6; MGEA; TALI; MGEA6; CTAGE5; MGEA11
    Summary
    This gene encodes s receptor in the endoplasmic reticulum, which plays a role in the export of large pre-chylomicrons and pre-very low density lipoproteins (pre-VLDLs). Three major classes of transcripts are generated from this gene- melanoma inhibitory activity 2-specific transcripts, cTAGE family member 5-specific transcripts and transcripts that include exons from both these transcript species (TANGO1-like or TALI). Additionally, alternative splicing in these transcripts results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Sep 2016]
    Expression
    Ubiquitous expression in small intestine (RPKM 22.6), duodenum (RPKM 22.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MIA2 in Genome Data Viewer
    Location:
    14q21.1
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (39233915..39388522)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (33422576..33577145)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (39703119..39857726)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene transmembrane protein 92 pseudogene Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:39672946-39674145 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8289 Neighboring gene YTH domain family member 2 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:39735794-39736376 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:39736377-39736957 Neighboring gene MIA2 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:39839799-39840298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:39839297-39839798 Neighboring gene GLRX5 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5689 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5690 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8290 Neighboring gene uncharacterized LOC105370461 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5691 Neighboring gene coilin pseudogene 1 Neighboring gene F-box protein 33 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8291 Neighboring gene uncharacterized LOC105370460 Neighboring gene uncharacterized LOC112267899

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ22404, FLJ31229, FLJ33933, FLJ55352, FLJ94735, FLJ96258, MGC59810, MGC75562, MGC163409, MGC163435, DKFZp313K0722, DKFZp686F2453, DKFZp686M2159, DKFZp779J1922, DKFZp779M1842, DKFZp686F08252

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cargo receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables enzyme activator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
     
    is_active_in endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum exit site IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in membrane HDA PubMed 

    General protein information

    Preferred Names
    melanoma inhibitory activity protein 2
    Names
    CTAGE family member 5, ER export factor
    CTAGE family, member 5
    MIA protein 2
    TANGO1-like
    cutaneous T-cell lymphoma-associated antigen 5
    melanoma inhibitory activity 2
    meningioma expressed antigen 6 (coiled-coil proline-rich)
    meningioma-expressed antigen 6/11
    protein cTAGE-5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030349.3 RefSeqGene

      Range
      4995..121774
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001247988.1NP_001234917.1  melanoma inhibitory activity protein 2 isoform 5

      See identical proteins and their annotated locations for NP_001234917.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence, lacks an alternate in-frame exon, and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 6. It encodes isoform 5, which is shorter at the N-terminus and lacks two internal segments compared to isoform 6. Variants 5 and 12 both encode the same isoform (5).
      Source sequence(s)
      AF338233, AI521895, AK091252, AL132639, AL833415
      UniProtKB/TrEMBL
      Q59FD2
      Conserved Domains (1) summary
      cl25732
      Location:45470
      SMC_N; RecF/RecN/SMC N terminal domain
    2. NM_001247989.2NP_001234918.1  melanoma inhibitory activity protein 2 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) represents the longest transcript and encodes the longest isoform (6, also known as TALI).
      Source sequence(s)
      AI521895, AL132639, BC064355, CV809109
      Consensus CDS
      CCDS58316.1
      UniProtKB/TrEMBL
      Q59FD2
      Related
      ENSP00000379462.2, ENST00000396158.6
      Conserved Domains (4) summary
      pfam06409
      Location:403476
      NPIP; Nuclear pore complex interacting protein (NPIP)
      pfam10211
      Location:164230
      Ax_dynein_light; Axonemal dynein light chain
      pfam14662
      Location:325496
      KASH_CCD; Coiled-coil region of CCDC155 or KASH
      pfam15233
      Location:350448
      SYCE1; Synaptonemal complex central element protein 1
    3. NM_001247990.2NP_001234919.1  melanoma inhibitory activity protein 2 isoform 7

      See identical proteins and their annotated locations for NP_001234919.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks a portion of the 5' coding region and initiates translation at a downstream start codon compared to variant 6. The resulting isoform (7) is shorter at the N-terminus compared to isoform 6.
      Source sequence(s)
      AI521895, AL132639, BC051363, CV809109
      Consensus CDS
      CCDS58317.1
      UniProtKB/TrEMBL
      Q59FD2
      Related
      ENSP00000452562.1, ENST00000556148.5
      Conserved Domains (1) summary
      cl25732
      Location:2424
      SMC_N; RecF/RecN/SMC N terminal domain
    4. NM_001329214.4NP_001316143.1  melanoma inhibitory activity protein 2 isoform 8 precursor

      Status: REVIEWED

      Source sequence(s)
      AL132639
      Consensus CDS
      CCDS86384.1
      UniProtKB/Swiss-Prot
      A0A193H6U5, A1L4H0, B3KRA6, B4DQS6, D3DSA6, G3XAC5, O00169, O15320, Q6MZN2, Q6P2R8, Q86TF6, Q8IX92, Q8IX93, Q96PC5, Q9H6C1
      UniProtKB/TrEMBL
      G3V599
      Related
      ENSP00000491014.1, ENST00000640607.2
    5. NM_001354137.2NP_001341066.1  melanoma inhibitory activity protein 2 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variants 4 and 11, encodes isoform 4.
      Source sequence(s)
      AL132639
      Consensus CDS
      CCDS9676.1
      UniProtKB/TrEMBL
      Q59FD2
      Conserved Domains (1) summary
      cl25732
      Location:45470
      SMC_N; RecF/RecN/SMC N terminal domain
    6. NM_001354138.1NP_001341067.1  melanoma inhibitory activity protein 2 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variants 4 and 10, encodes isoform 4.
      Source sequence(s)
      AL132639
      Consensus CDS
      CCDS9676.1
      UniProtKB/TrEMBL
      Q59FD2
      Related
      ENSP00000450449.1, ENST00000553352.1
      Conserved Domains (1) summary
      cl25732
      Location:45470
      SMC_N; RecF/RecN/SMC N terminal domain
    7. NM_001354139.2NP_001341068.1  melanoma inhibitory activity protein 2 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variant 5, encodes isoform 5.
      Source sequence(s)
      AL132639
      UniProtKB/TrEMBL
      Q59FD2
      Conserved Domains (1) summary
      cl25732
      Location:45470
      SMC_N; RecF/RecN/SMC N terminal domain
    8. NM_001354140.2NP_001341069.1  melanoma inhibitory activity protein 2 isoform 10

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variant 14, encodes isoform 10.
      Source sequence(s)
      AL132639
      Consensus CDS
      CCDS86386.1
      UniProtKB/TrEMBL
      Q59FD2
      Related
      ENSP00000450869.1, ENST00000557038.5
      Conserved Domains (1) summary
      cl25732
      Location:87380
      SMC_N; RecF/RecN/SMC N terminal domain
    9. NM_001354141.2NP_001341070.1  melanoma inhibitory activity protein 2 isoform 10

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variant 13, encodes isoform 10.
      Source sequence(s)
      AL132639
      Consensus CDS
      CCDS86386.1
      UniProtKB/TrEMBL
      Q59FD2
      Conserved Domains (1) summary
      cl25732
      Location:87380
      SMC_N; RecF/RecN/SMC N terminal domain
    10. NM_001354142.1NP_001341071.1  melanoma inhibitory activity protein 2 isoform 11

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variants 16 and 17, encodes isoform 11.
      Source sequence(s)
      AL132639
      UniProtKB/TrEMBL
      Q59FD2
      Conserved Domains (1) summary
      cl25732
      Location:87380
      SMC_N; RecF/RecN/SMC N terminal domain
    11. NM_001354143.1NP_001341072.1  melanoma inhibitory activity protein 2 isoform 11

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variants 15 and 17, encodes isoform 11.
      Source sequence(s)
      AL132639
      UniProtKB/TrEMBL
      Q59FD2
      Conserved Domains (1) summary
      cl25732
      Location:87380
      SMC_N; RecF/RecN/SMC N terminal domain
    12. NM_001354144.2NP_001341073.1  melanoma inhibitory activity protein 2 isoform 11

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variants 15 and 16, encodes isoform 11.
      Source sequence(s)
      AL132639
      UniProtKB/TrEMBL
      Q59FD2
      Conserved Domains (1) summary
      cl25732
      Location:87380
      SMC_N; RecF/RecN/SMC N terminal domain
    13. NM_001354145.2NP_001341074.1  melanoma inhibitory activity protein 2 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AL132639, AL157791
      Conserved Domains (1) summary
      cl25732
      Location:87380
      SMC_N; RecF/RecN/SMC N terminal domain
    14. NM_001354146.2NP_001341075.1  melanoma inhibitory activity protein 2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AL132639
      UniProtKB/TrEMBL
      Q59FD2
      Conserved Domains (1) summary
      cl25732
      Location:62487
      SMC_N; RecF/RecN/SMC N terminal domain
    15. NM_001354147.1NP_001341076.1  melanoma inhibitory activity protein 2 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AL132639
      UniProtKB/TrEMBL
      Q59FD2
      Conserved Domains (1) summary
      cl25732
      Location:112405
      SMC_N; RecF/RecN/SMC N terminal domain
    16. NM_001354148.1NP_001341077.1  melanoma inhibitory activity protein 2 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AL132639, AL157791
      UniProtKB/TrEMBL
      Q59FD2
      Conserved Domains (1) summary
      cl25732
      Location:45470
      SMC_N; RecF/RecN/SMC N terminal domain
    17. NM_001354149.1NP_001341078.1  melanoma inhibitory activity protein 2 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AL132639
      UniProtKB/TrEMBL
      Q59FD2
      Conserved Domains (1) summary
      cl25732
      Location:112405
      SMC_N; RecF/RecN/SMC N terminal domain
    18. NM_001354150.2NP_001341079.1  melanoma inhibitory activity protein 2 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AL132639
      UniProtKB/TrEMBL
      Q59FD2
      Conserved Domains (1) summary
      cl25732
      Location:68493
      SMC_N; RecF/RecN/SMC N terminal domain
    19. NM_001354151.2NP_001341080.1  melanoma inhibitory activity protein 2 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AL132639
      UniProtKB/TrEMBL
      Q59FD2
      Conserved Domains (1) summary
      cl25732
      Location:74508
      SMC_N; RecF/RecN/SMC N terminal domain
    20. NM_001354152.3NP_001341081.1  melanoma inhibitory activity protein 2 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AL132639
      UniProtKB/TrEMBL
      Q59FD2
      Conserved Domains (1) summary
      cl25732
      Location:74508
      SMC_N; RecF/RecN/SMC N terminal domain
    21. NM_001354153.2NP_001341082.1  melanoma inhibitory activity protein 2 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AL132639
      UniProtKB/TrEMBL
      Q59FD2
      Conserved Domains (1) summary
      cl25732
      Location:141434
      SMC_N; RecF/RecN/SMC N terminal domain
    22. NM_001354154.2NP_001341083.1  melanoma inhibitory activity protein 2 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AL132639, AL157791
      Consensus CDS
      CCDS86385.1
      UniProtKB/TrEMBL
      Q59FD2
      Related
      ENSP00000339286.5, ENST00000341502.9
      Conserved Domains (1) summary
      cl25732
      Location:74499
      SMC_N; RecF/RecN/SMC N terminal domain
    23. NM_001354155.2NP_001341084.1  melanoma inhibitory activity protein 2 isoform 22

      Status: REVIEWED

      Source sequence(s)
      AL132639, AL157791
      UniProtKB/TrEMBL
      Q59FD2
      Conserved Domains (1) summary
      cl25732
      Location:74499
      SMC_N; RecF/RecN/SMC N terminal domain
    24. NM_001354156.2NP_001341085.1  melanoma inhibitory activity protein 2 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AL132639
      UniProtKB/TrEMBL
      Q59FD2
      Conserved Domains (1) summary
      cl25732
      Location:1338
      SMC_N; RecF/RecN/SMC N terminal domain
    25. NM_001354157.2NP_001341086.1  melanoma inhibitory activity protein 2 isoform 24

      Status: REVIEWED

      Source sequence(s)
      AL132639
      UniProtKB/TrEMBL
      Q59FD2
      Conserved Domains (1) summary
      cl25732
      Location:141434
      SMC_N; RecF/RecN/SMC N terminal domain
    26. NM_005930.4NP_005921.2  melanoma inhibitory activity protein 2 isoform 1

      See identical proteins and their annotated locations for NP_005921.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 6. It encodes isoform 1, which lacks an internal segment compared to isoform 6.
      Source sequence(s)
      AB209528, AL132639, CV809109, U94780
      Consensus CDS
      CCDS9674.1
      UniProtKB/TrEMBL
      Q59FD2
      Related
      ENSP00000280083.3, ENST00000280083.7
      Conserved Domains (4) summary
      pfam06409
      Location:398471
      NPIP; Nuclear pore complex interacting protein (NPIP)
      pfam10211
      Location:159225
      Ax_dynein_light; Axonemal dynein light chain
      pfam14662
      Location:320491
      KASH_CCD; Coiled-coil region of CCDC155 or KASH
      pfam15233
      Location:345443
      SYCE1; Synaptonemal complex central element protein 1
    27. NM_054024.4NP_473365.3  melanoma inhibitory activity protein 2 isoform 9 precursor

      See identical proteins and their annotated locations for NP_473365.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) has lacks several 3' exons and differs in the 3' coding region and 3' UTR, compared to variant 6. It encodes isoform 8, which has a shorter and distinct C-terminus, compared to isoform 6.
      Source sequence(s)
      AF390175, AK026057, AL132639, BX495701, BX648228
      Consensus CDS
      CCDS9672.1
      UniProtKB/Swiss-Prot
      Q96PC5
      Related
      ENSP00000280082.3, ENST00000280082.4
      Conserved Domains (1) summary
      cd11892
      Location:31103
      SH3_MIA2; Src Homology 3 domain of Melanoma Inhibitory Activity 2 protein
    28. NM_203354.3NP_976229.1  melanoma inhibitory activity protein 2 isoform 2

      See identical proteins and their annotated locations for NP_976229.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 6. It encodes isoform 2, which has a shorter and distinct N-terminus and lacks an internal segment compared to isoform 6.
      Source sequence(s)
      AB209528, AL132639, DA072098
      Consensus CDS
      CCDS9673.1
      UniProtKB/TrEMBL
      Q59FD2
      Related
      ENSP00000343897.3, ENST00000341749.7
      Conserved Domains (3) summary
      pfam06409
      Location:386459
      NPIP; Nuclear pore complex interacting protein (NPIP)
      pfam10211
      Location:147213
      Ax_dynein_light; Axonemal dynein light chain
      pfam15233
      Location:333431
      SYCE1; Synaptonemal complex central element protein 1
    29. NM_203355.3NP_976230.1  melanoma inhibitory activity protein 2 isoform 3

      See identical proteins and their annotated locations for NP_976230.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 6. It encodes isoform 3, which lacks two internal segments and is shorter, compared to isoform 6.
      Source sequence(s)
      AL132639, BC029513, CV809109
      Consensus CDS
      CCDS9675.1
      UniProtKB/TrEMBL
      Q59FD2
      Related
      ENSP00000343912.3, ENST00000348007.7
      Conserved Domains (4) summary
      pfam06409
      Location:398471
      NPIP; Nuclear pore complex interacting protein (NPIP)
      pfam10211
      Location:159225
      Ax_dynein_light; Axonemal dynein light chain
      pfam14662
      Location:320491
      KASH_CCD; Coiled-coil region of CCDC155 or KASH
      pfam15233
      Location:345443
      SYCE1; Synaptonemal complex central element protein 1
    30. NM_203356.2NP_976231.1  melanoma inhibitory activity protein 2 isoform 4

      See identical proteins and their annotated locations for NP_976231.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence, initiates translation at a downstream start codon, and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 6. It encodes isoform 4, which is shorter at the N-terminus and lacks an internal segment compared to isoform 6. Unlike the other variants, this variant may exhibit testis-specific expression. Variants 4, 10, and 11 all encode the same isoform (4).
      Source sequence(s)
      AF338233, AL132639
      Consensus CDS
      CCDS9676.1
      UniProtKB/TrEMBL
      Q59FD2
      Related
      ENSP00000379468.4, ENST00000396165.8
      Conserved Domains (1) summary
      cl25732
      Location:45470
      SMC_N; RecF/RecN/SMC N terminal domain

    RNA

    1. NR_148721.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL132639
    2. NR_148722.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL132639
    3. NR_148723.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL132639

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      39233915..39388522
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024449592.2XP_024305360.1  melanoma inhibitory activity protein 2 isoform X1

      UniProtKB/TrEMBL
      G3V599
      Conserved Domains (2) summary
      cd11892
      Location:31103
      SH3_MIA2; Src Homology 3 domain of Melanoma Inhibitory Activity 2 protein
      COG0419
      Location:6821121
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    2. XM_024449595.2XP_024305363.1  melanoma inhibitory activity protein 2 isoform X4

      UniProtKB/TrEMBL
      G3V599
      Conserved Domains (2) summary
      cd11892
      Location:31103
      SH3_MIA2; Src Homology 3 domain of Melanoma Inhibitory Activity 2 protein
      COG0419
      Location:6821121
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    3. XM_024449594.2XP_024305362.1  melanoma inhibitory activity protein 2 isoform X3

      UniProtKB/TrEMBL
      G3V599
      Conserved Domains (2) summary
      cd11892
      Location:31103
      SH3_MIA2; Src Homology 3 domain of Melanoma Inhibitory Activity 2 protein
      COG0419
      Location:6821112
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    4. XM_047431398.1XP_047287354.1  melanoma inhibitory activity protein 2 isoform X5

      UniProtKB/TrEMBL
      G3V599
    5. XM_024449593.2XP_024305361.1  melanoma inhibitory activity protein 2 isoform X2

      UniProtKB/TrEMBL
      G3V599
      Conserved Domains (2) summary
      cd11892
      Location:31103
      SH3_MIA2; Src Homology 3 domain of Melanoma Inhibitory Activity 2 protein
      COG0419
      Location:6821116
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    6. XM_024449596.2XP_024305364.1  melanoma inhibitory activity protein 2 isoform X6

      UniProtKB/TrEMBL
      G3V599
      Conserved Domains (2) summary
      cd11892
      Location:31103
      SH3_MIA2; Src Homology 3 domain of Melanoma Inhibitory Activity 2 protein
      COG0419
      Location:6821107
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    7. XM_047431399.1XP_047287355.1  melanoma inhibitory activity protein 2 isoform X7

      UniProtKB/TrEMBL
      G3V599
    8. XM_024449597.2XP_024305365.1  melanoma inhibitory activity protein 2 isoform X8

      UniProtKB/TrEMBL
      G3V599
      Conserved Domains (2) summary
      cd11892
      Location:31103
      SH3_MIA2; Src Homology 3 domain of Melanoma Inhibitory Activity 2 protein
      COG0419
      Location:6821121
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    9. XM_047431401.1XP_047287357.1  melanoma inhibitory activity protein 2 isoform X9

      UniProtKB/TrEMBL
      G3V599
    10. XM_047431402.1XP_047287358.1  melanoma inhibitory activity protein 2 isoform X10

    11. XM_017021316.2XP_016876805.1  melanoma inhibitory activity protein 2 isoform X13

      UniProtKB/TrEMBL
      Q59FD2
    12. XM_047431403.1XP_047287359.1  melanoma inhibitory activity protein 2 isoform X15

      UniProtKB/TrEMBL
      Q59FD2
    13. XM_047431409.1XP_047287365.1  melanoma inhibitory activity protein 2 isoform X21

      UniProtKB/TrEMBL
      Q59FD2
    14. XM_011536778.3XP_011535080.1  melanoma inhibitory activity protein 2 isoform X14

      UniProtKB/TrEMBL
      Q59FD2
      Conserved Domains (3) summary
      pfam06409
      Location:395468
      NPIP; Nuclear pore complex interacting protein (NPIP)
      pfam10211
      Location:156222
      Ax_dynein_light; Axonemal dynein light chain
      pfam15233
      Location:342440
      SYCE1; Synaptonemal complex central element protein 1
    15. XM_017021324.3XP_016876813.1  melanoma inhibitory activity protein 2 isoform X22

      UniProtKB/TrEMBL
      Q59FD2
      Conserved Domains (1) summary
      cl25732
      Location:5433
      SMC_N; RecF/RecN/SMC N terminal domain
    16. XM_017021317.3XP_016876806.1  melanoma inhibitory activity protein 2 isoform X16

      UniProtKB/TrEMBL
      Q59FD2
    17. XM_024449598.2XP_024305366.1  melanoma inhibitory activity protein 2 isoform X22

      UniProtKB/TrEMBL
      Q59FD2
      Conserved Domains (1) summary
      cl25732
      Location:5433
      SMC_N; RecF/RecN/SMC N terminal domain
    18. XM_017021330.2XP_016876819.1  melanoma inhibitory activity protein 2 isoform X16

      UniProtKB/TrEMBL
      Q59FD2
    19. XM_017021315.3XP_016876804.1  melanoma inhibitory activity protein 2 isoform X12

      UniProtKB/TrEMBL
      Q59FD2
    20. XM_047431408.1XP_047287364.1  melanoma inhibitory activity protein 2 isoform X20

      UniProtKB/TrEMBL
      Q59FD2
    21. XM_017021318.2XP_016876807.1  melanoma inhibitory activity protein 2 isoform X16

      UniProtKB/TrEMBL
      Q59FD2
    22. XM_017021319.2XP_016876808.1  melanoma inhibitory activity protein 2 isoform X16

      UniProtKB/TrEMBL
      Q59FD2
    23. XM_047431406.1XP_047287362.1  melanoma inhibitory activity protein 2 isoform X18

      UniProtKB/TrEMBL
      Q59FD2
    24. XM_047431405.1XP_047287361.1  melanoma inhibitory activity protein 2 isoform X17

      UniProtKB/TrEMBL
      Q59FD2
    25. XM_047431411.1XP_047287367.1  melanoma inhibitory activity protein 2 isoform X23

      UniProtKB/TrEMBL
      Q59FD2
    26. XM_047431410.1XP_047287366.1  melanoma inhibitory activity protein 2 isoform X22

      UniProtKB/TrEMBL
      Q59FD2
    27. XM_017021314.2XP_016876803.1  melanoma inhibitory activity protein 2 isoform X11

      UniProtKB/TrEMBL
      Q59FD2
    28. XM_047431407.1XP_047287363.1  melanoma inhibitory activity protein 2 isoform X19

      UniProtKB/TrEMBL
      Q59FD2
    29. XM_017021323.2XP_016876812.1  melanoma inhibitory activity protein 2 isoform X22

      UniProtKB/TrEMBL
      Q59FD2
      Conserved Domains (1) summary
      cl25732
      Location:5433
      SMC_N; RecF/RecN/SMC N terminal domain
    30. XM_047431412.1XP_047287368.1  melanoma inhibitory activity protein 2 isoform X24

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      33422576..33577145
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376085.1XP_054232060.1  melanoma inhibitory activity protein 2 isoform X1

      UniProtKB/TrEMBL
      G3V599
    2. XM_054376088.1XP_054232063.1  melanoma inhibitory activity protein 2 isoform X4

      UniProtKB/TrEMBL
      G3V599
    3. XM_054376087.1XP_054232062.1  melanoma inhibitory activity protein 2 isoform X3

      UniProtKB/TrEMBL
      G3V599
    4. XM_054376089.1XP_054232064.1  melanoma inhibitory activity protein 2 isoform X5

      UniProtKB/TrEMBL
      G3V599
    5. XM_054376086.1XP_054232061.1  melanoma inhibitory activity protein 2 isoform X2

      UniProtKB/TrEMBL
      G3V599
    6. XM_054376090.1XP_054232065.1  melanoma inhibitory activity protein 2 isoform X6

      UniProtKB/TrEMBL
      G3V599
    7. XM_054376091.1XP_054232066.1  melanoma inhibitory activity protein 2 isoform X7

      UniProtKB/TrEMBL
      G3V599
    8. XM_054376092.1XP_054232067.1  melanoma inhibitory activity protein 2 isoform X8

      UniProtKB/TrEMBL
      G3V599
    9. XM_054376093.1XP_054232068.1  melanoma inhibitory activity protein 2 isoform X9

      UniProtKB/TrEMBL
      G3V599
    10. XM_054376094.1XP_054232069.1  melanoma inhibitory activity protein 2 isoform X10

    11. XM_054376097.1XP_054232072.1  melanoma inhibitory activity protein 2 isoform X13

      UniProtKB/TrEMBL
      Q59FD2
    12. XM_054376099.1XP_054232074.1  melanoma inhibitory activity protein 2 isoform X15

      UniProtKB/TrEMBL
      Q59FD2
    13. XM_054376107.1XP_054232082.1  melanoma inhibitory activity protein 2 isoform X21

      UniProtKB/TrEMBL
      Q59FD2
    14. XM_054376098.1XP_054232073.1  melanoma inhibitory activity protein 2 isoform X14

      UniProtKB/TrEMBL
      Q59FD2
    15. XM_054376108.1XP_054232083.1  melanoma inhibitory activity protein 2 isoform X22

      UniProtKB/TrEMBL
      Q59FD2
    16. XM_054376100.1XP_054232075.1  melanoma inhibitory activity protein 2 isoform X16

      UniProtKB/TrEMBL
      Q59FD2
    17. XM_054376110.1XP_054232085.1  melanoma inhibitory activity protein 2 isoform X22

      UniProtKB/TrEMBL
      Q59FD2
    18. XM_054376096.1XP_054232071.1  melanoma inhibitory activity protein 2 isoform X12

      UniProtKB/TrEMBL
      Q59FD2
    19. XM_054376106.1XP_054232081.1  melanoma inhibitory activity protein 2 isoform X20

      UniProtKB/TrEMBL
      Q59FD2
    20. XM_054376113.1XP_054232088.1  melanoma inhibitory activity protein 2 isoform X16

      UniProtKB/TrEMBL
      Q59FD2
    21. XM_054376101.1XP_054232076.1  melanoma inhibitory activity protein 2 isoform X16

      UniProtKB/TrEMBL
      Q59FD2
    22. XM_054376102.1XP_054232077.1  melanoma inhibitory activity protein 2 isoform X16

      UniProtKB/TrEMBL
      Q59FD2
    23. XM_054376104.1XP_054232079.1  melanoma inhibitory activity protein 2 isoform X18

      UniProtKB/TrEMBL
      Q59FD2
    24. XM_054376103.1XP_054232078.1  melanoma inhibitory activity protein 2 isoform X17

      UniProtKB/TrEMBL
      Q59FD2
    25. XM_054376112.1XP_054232087.1  melanoma inhibitory activity protein 2 isoform X23

      UniProtKB/TrEMBL
      Q59FD2
    26. XM_054376111.1XP_054232086.1  melanoma inhibitory activity protein 2 isoform X22

      UniProtKB/TrEMBL
      Q59FD2
    27. XM_054376095.1XP_054232070.1  melanoma inhibitory activity protein 2 isoform X11

      UniProtKB/TrEMBL
      Q59FD2
    28. XM_054376105.1XP_054232080.1  melanoma inhibitory activity protein 2 isoform X19

      UniProtKB/TrEMBL
      Q59FD2
    29. XM_054376109.1XP_054232084.1  melanoma inhibitory activity protein 2 isoform X22

      UniProtKB/TrEMBL
      Q59FD2
    30. XM_054376114.1XP_054232089.1  melanoma inhibitory activity protein 2 isoform X24

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_203357.1: Suppressed sequence

      Description
      NM_203357.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.