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    ANAPC13 anaphase promoting complex subunit 13 [ Homo sapiens (human) ]

    Gene ID: 25847, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ANAPC13provided by HGNC
    Official Full Name
    anaphase promoting complex subunit 13provided by HGNC
    Primary source
    HGNC:HGNC:24540
    See related
    Ensembl:ENSG00000129055 MIM:614484; AllianceGenome:HGNC:24540
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SWM1; APC13
    Summary
    This gene encodes a component of the anaphase promoting complex, a large ubiquitin-protein ligase that controls cell cycle progression by regulating the degradation of cell cycle regulators such as B-type cyclins. The encoded protein is evolutionarily conserved and is required for the integrity and ubiquitin ligase activity of the anaphase promoting complex. Pseudogenes and splice variants have been found for this gene; however, the biological validity of some of the splice variants has not been determined. [provided by RefSeq, Nov 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 36.9), kidney (RPKM 32.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ANAPC13 in Genome Data Viewer
    Location:
    3q22.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (134477704..134486023, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (137222876..137231191, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (134196546..134204865, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:134124670-134125376 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:134126084-134126789 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:134145749-134146948 Neighboring gene high mobility group box 3 pseudogene 13 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:134181408-134182134 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:134183586-134184310 Neighboring gene microRNA 4788 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20563 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:134205013-134205831 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20564 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20562 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20565 Neighboring gene centrosomal protein 63 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:134245816-134246316 Neighboring gene DPPA4 pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 9743 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:134338253-134338753 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:134361872-134362713 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:134362971-134363635 Neighboring gene kyphoscoliosis peptidase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. The anaphase-promoting complex: a key factor in the regulation of cell cycle. Castro A, et al. Oncogene, 2005 Jan 13. PMID 15678131
    2. Lesson from the stoichiometry determination of the cohesin complex: a short protease mediated elution increases the recovery from cross-linked antibody-conjugated beads. Holzmann J, et al. J Proteome Res, 2011 Feb 4. PMID 21043528, Free PMC Article
    3. Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control. Yau RG, et al. Cell, 2017 Nov 2. PMID 29033132, Free PMC Article
    4. Atomic structure of the APC/C and its mechanism of protein ubiquitination. Chang L, et al. Nature, 2015 Jun 25. PMID 26083744, Free PMC Article
    5. Molecular architecture and mechanism of the anaphase-promoting complex. Chang LF, et al. Nature, 2014 Sep 18. PMID 25043029, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association analysis identifies 20 loci that influence adult height.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp566D193

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in anaphase-promoting complex-dependent catabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K11-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K11-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein branched polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of meiotic cell cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of anaphase-promoting complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of anaphase-promoting complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    anaphase-promoting complex subunit 13
    Names
    cyclosome subunit 13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242374.1 → NP_001229303.1  anaphase-promoting complex subunit 13

      See identical proteins and their annotated locations for NP_001229303.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC010207, AK290761, AV682398, BU627217
      Consensus CDS
      CCDS3085.1
      UniProtKB/Swiss-Prot
      Q9BS18, Q9Y3V0
      UniProtKB/TrEMBL
      A6NJK6, A8K3Z6, D3DND5
      Related
      ENSP00000421842.1, ENST00000510994.5
      Conserved Domains (1) summary
      pfam05839
      Location:1 → 74
      Apc13p; Apc13p protein

    2. NM_001242375.1 → NP_001229304.1  anaphase-promoting complex subunit 13

      See identical proteins and their annotated locations for NP_001229304.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 2. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC010207, AV682398, BU627217, CN258858
      Consensus CDS
      CCDS3085.1
      UniProtKB/Swiss-Prot
      Q9BS18, Q9Y3V0
      UniProtKB/TrEMBL
      A6NJK6, A8K3Z6, D3DND5
      Related
      ENSP00000427327.1, ENST00000514612.5
      Conserved Domains (1) summary
      pfam05839
      Location:1 → 74
      Apc13p; Apc13p protein

    3. NM_015391.4 → NP_056206.1  anaphase-promoting complex subunit 13

      See identical proteins and their annotated locations for NP_056206.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK026550, BC005398
      Consensus CDS
      CCDS3085.1
      UniProtKB/Swiss-Prot
      Q9BS18, Q9Y3V0
      UniProtKB/TrEMBL
      A6NJK6, A8K3Z6, D3DND5
      Related
      ENSP00000346987.5, ENST00000354910.10
      Conserved Domains (1) summary
      pfam05839
      Location:1 → 74
      Apc13p; Apc13p protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      134477704..134486023 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      137222876..137231191 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BS18.1 GenPept UniProtKB/Swiss-Prot:Q9BS18

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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