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    Ncl nucleolin [ Mus musculus (house mouse) ]

    Gene ID: 17975, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nclprovided by MGI
    Official Full Name
    nucleolinprovided by MGI
    Primary source
    MGI:MGI:97286
    See related
    Ensembl:ENSMUSG00000026234 AllianceGenome:MGI:97286
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C23; Nucl; D0Nds28; D1Nds28; B530004O11Rik
    Summary
    Enables PH domain binding activity; RNA binding activity; and insulin receptor substrate binding activity. Acts upstream of or within several processes, including cellular response to epidermal growth factor stimulus; cellular response to leukemia inhibitory factor; and negative regulation of insulin receptor signaling pathway. Located in nucleolus and nucleoplasm. Is active in cornified envelope. Is expressed in several structures, including 1st branchial arch mandibular component; blastocyst; central nervous system; early embryo; and tooth. Orthologous to human NCL (nucleolin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E11.5 (RPKM 52.4), liver E14 (RPKM 41.1) and 11 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ncl in Genome Data Viewer
    Location:
    1 C5; 1 43.94 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (86272441..86287177, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (86344719..86359455, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated B3gnt7 cis-regulatory element Neighboring gene predicted gene 28626 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 Neighboring gene predicted gene 5258 Neighboring gene STARR-seq mESC enhancer starr_01572 Neighboring gene small nucleolar RNA, H/ACA box 75 Neighboring gene microRNA 3535 Neighboring gene RIKEN cDNA C130036L24 gene Neighboring gene STARR-positive B cell enhancer ABC_E406 Neighboring gene small nucleolar RNA, C/D box 82 Neighboring gene neuromedin U receptor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA topoisomerase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA topoisomerase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ErbB-4 class receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables PH domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables insulin receptor substrate binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables laminin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA 5'-UTR binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA 5'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables rRNA primary transcript binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables selenocysteine insertion sequence binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables telomeric DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to epidermal growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of rRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cornified envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic ribonucleoprotein granule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dense fibrillar component ISO
    Inferred from Sequence Orthology
    more info
     
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010880.3NP_035010.3  nucleolin

      See identical proteins and their annotated locations for NP_035010.3

      Status: VALIDATED

      Source sequence(s)
      AC102609, AK144894, CJ084318
      Consensus CDS
      CCDS35646.1
      UniProtKB/Swiss-Prot
      P09405, Q548M9, Q61991, Q8BQD8, Q99K50
      UniProtKB/TrEMBL
      Q3TGR3, Q3TT41
      Related
      ENSMUSP00000027438.7, ENSMUST00000027438.8
      Conserved Domains (4) summary
      cd12403
      Location:309383
      RRM1_NCL; RNA recognition motif 1 in vertebrate nucleolin
      cd12404
      Location:392467
      RRM2_NCL; RNA recognition motif 2 in vertebrate nucleolin
      cd12405
      Location:486558
      RRM3_NCL; RNA recognition motif 3 in vertebrate nucleolin
      cd12406
      Location:569646
      RRM4_NCL; RNA recognition motif 4 in vertebrate nucleolin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      86272441..86287177 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529238.4XP_006529301.1  nucleolin isoform X1

      UniProtKB/TrEMBL
      Q3TGR3, Q3TT41
      Conserved Domains (5) summary
      PRK10905
      Location:34124
      PRK10905; cell division protein DamX; Validated
      cd12403
      Location:293367
      RRM1_NCL; RNA recognition motif 1 in vertebrate nucleolin
      cd12404
      Location:376451
      RRM2_NCL; RNA recognition motif 2 in vertebrate nucleolin
      cd12405
      Location:470542
      RRM3_NCL; RNA recognition motif 3 in vertebrate nucleolin
      cd12406
      Location:553630
      RRM4_NCL; RNA recognition motif 4 in vertebrate nucleolin