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    U90926 cDNA sequence U90926 [ Mus musculus (house mouse) ]

    Gene ID: 57425, updated on 9-Dec-2024

    Summary

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    Official Symbol
    U90926provided by MGI
    Official Full Name
    cDNA sequence U90926provided by MGI
    Primary source
    MGI:MGI:1930915
    See related
    Ensembl:ENSMUSG00000029409 AllianceGenome:MGI:1930915
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Involved in innate immune response. Located in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See U90926 in Genome Data Viewer
    Location:
    5 E2; 5 46.23 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (92357754..92363211, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (92209895..92215408, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L13 pseudogene Neighboring gene USO1 vesicle docking factor Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:92612573-92612756 Neighboring gene predicted gene, 25290 Neighboring gene predicted gene, 42113 Neighboring gene predicted gene, 42112 Neighboring gene protein phosphatase, EF hand calcium-binding domain 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:92674514-92674783

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LncRNA U90926 is dispensable for the development of obesity-associated phenotypes in vivo. Sabikunnahar B, et al. Physiol Rep, 2024 Jan. PMID 38171546, Free PMC Article
    2. Cryptosporidium parvum hijacks a host's long noncoding RNA U90926 to evade intestinal epithelial cell-autonomous antiparasitic defense. Graham ML, et al. Front Immunol, 2023. PMID 37346046, Free PMC Article
    3. Long Noncoding RNA U90926 Is Induced in Activated Macrophages, Is Protective in Endotoxic Shock, and Encodes a Novel Secreted Protein. Sabikunnahar B, et al. J Immunol, 2023 Mar 15. PMID 36705532, Free PMC Article
    4. Microglial lnc-U90926 facilitates neutrophil infiltration in ischemic stroke via MDH2/CXCL2 axis. Chen J, et al. Mol Ther, 2021 Sep 1. PMID 33895326, Free PMC Article
    5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, et al. Nature, 2002 Dec 5. PMID 12466851

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cryptosporidium parvum hijacks a host's long noncoding RNA U90926 to evade intestinal epithelial cell-autonomous antiparasitic defense.
      Title: Cryptosporidium parvum hijacks a host's long noncoding RNA U90926 to evade intestinal epithelial cell-autonomous antiparasitic defense.
    2. Long Noncoding RNA U90926 Is Induced in Activated Macrophages, Is Protective in Endotoxic Shock, and Encodes a Novel Secreted Protein.
      Title: Long Noncoding RNA U90926 Is Induced in Activated Macrophages, Is Protective in Endotoxic Shock, and Encodes a Novel Secreted Protein.
    3. Microglial lnc-U90926 facilitates neutrophil infiltration in ischemic stroke via MDH2/CXCL2 axis.
      Title: Microglial lnc-U90926 facilitates neutrophil infiltration in ischemic stroke via MDH2/CXCL2 axis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    endotoxic shock protective protein U9-ORF
    Names
    U9-ORF protein
    putative TNF-resistance related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001416553.1 → NP_001403482.1  endotoxic shock protective protein U9-ORF precursor

      Status: VALIDATED

      Source sequence(s)
      AC125542
      UniProtKB/Swiss-Prot
      O08546
      Related
      ENSMUSP00000159852.1, ENSMUST00000201332.5

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      92357754..92363211 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_020562.1: Suppressed sequence

      Description
      NM_020562.1: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.

    2. NR_033483.1: Suppressed sequence

      Description
      NR_033483.1: This RefSeq was removed because it is now thought that this gene does encode a protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08546.2 GenPept UniProtKB/Swiss-Prot:O08546

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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