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    Pla2g5 phospholipase A2, group V [ Mus musculus (house mouse) ]

    Gene ID: 18784, updated on 3-Dec-2024

    Summary

    Official Symbol
    Pla2g5provided by MGI
    Official Full Name
    phospholipase A2, group Vprovided by MGI
    Primary source
    MGI:MGI:101899
    See related
    Ensembl:ENSMUSG00000041193 AllianceGenome:MGI:101899
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PLA2; sPLA2; PLA2-10
    Summary
    Enables phospholipase A2 activity and signaling receptor binding activity. Involved in several processes, including arachidonate secretion; low-density lipoprotein particle remodeling; and positive regulation of immune effector process. Acts upstream of or within negative regulation of inflammatory response and regulation of macrophage activation. Located in cell surface; early phagosome; and phagolysosome. Is expressed in several structures, including central nervous system; ear; genitourinary system; liver; and peripheral nervous system ganglion. Human ortholog(s) of this gene implicated in familial benign fleck retina. Orthologous to human PLA2G5 (phospholipase A2 group V). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in adrenal adult (RPKM 10.0), heart adult (RPKM 9.8) and 12 other tissues See more
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    Genomic context

    See Pla2g5 in Genome Data Viewer
    Location:
    4 D3; 4 70.57 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (138526558..138590784, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (138799247..138863562, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42332 Neighboring gene predicted gene, 32871 Neighboring gene phospholipase A2, group IID Neighboring gene STARR-seq mESC enhancer starr_11818 Neighboring gene predicted gene, 25280 Neighboring gene phospholipase A2, group IIA (platelets, synovial fluid) Neighboring gene STARR-positive B cell enhancer mm9_chr4:138412463-138412764 Neighboring gene STARR-positive B cell enhancer mm9_chr4:138422386-138422686 Neighboring gene predicted gene, 32930 Neighboring gene predicted gene 13030

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium-dependent phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium-dependent phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium-dependent phospholipase A2 activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium-independent phospholipase A2 activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium-independent phospholipase A2 activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipase A2 activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in arachidonate secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in arachidonate secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiolipin acyl-chain remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiolipin acyl-chain remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in leukotriene biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in leukotriene biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in low-density lipoprotein particle remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within low-density lipoprotein particle remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of T cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phagosome-lysosome fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phosphatidylcholine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylcholine catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phosphatidylcholine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylglycerol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phospholipid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in platelet activating factor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of antifungal innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of immune complex clearance by monocytes and macrophages IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of immune complex clearance by monocytes and macrophages ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of macrophage derived foam cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of opsonization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of phagosome maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of phospholipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of macrophage activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early phagosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in phagolysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    phospholipase A2 group V
    Names
    calcium-dependent phospholipase A2
    group V phospholipase A2
    phosphatidylcholine 2-acylhydrolase 5
    NP_001116426.1
    NP_001411736.1
    NP_001411737.1
    NP_035240.3
    XP_006538721.2
    XP_017175533.1
    XP_036019728.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122954.2NP_001116426.1  phospholipase A2 group V precursor

      See identical proteins and their annotated locations for NP_001116426.1

      Status: VALIDATED

      Source sequence(s)
      AL844178
      Consensus CDS
      CCDS18834.1
      UniProtKB/Swiss-Prot
      P97391, Q9QZU6
      UniProtKB/TrEMBL
      E9PZD1, Q6GTW1
      Related
      ENSMUSP00000030524.8, ENSMUST00000030524.14
      Conserved Domains (1) summary
      cd00125
      Location:21137
      PLA2c; Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a metal-dependent ...
    2. NM_001424807.1NP_001411736.1  phospholipase A2 group V precursor

      Status: VALIDATED

      Source sequence(s)
      AL844178
      UniProtKB/Swiss-Prot
      P97391, Q9QZU6
      UniProtKB/TrEMBL
      E9PZD1, Q6GTW1
    3. NM_001424808.1NP_001411737.1  phospholipase A2 group V precursor

      Status: VALIDATED

      Source sequence(s)
      AL844178
      UniProtKB/Swiss-Prot
      P97391, Q9QZU6
      UniProtKB/TrEMBL
      E9PZD1, Q6GTW1
    4. NM_001429587.1NP_001416516.1  phospholipase A2 group V precursor

      Status: VALIDATED

      Source sequence(s)
      AL844178
      UniProtKB/Swiss-Prot
      P97391, Q9QZU6
      UniProtKB/TrEMBL
      E9PZD1, Q6GTW1
    5. NM_001429591.1NP_001416520.1  phospholipase A2 group V precursor

      Status: VALIDATED

      Source sequence(s)
      AL844178
      UniProtKB/Swiss-Prot
      P97391, Q9QZU6
      UniProtKB/TrEMBL
      E9PZD1, Q6GTW1
    6. NM_011110.5NP_035240.3  phospholipase A2 group V precursor

      See identical proteins and their annotated locations for NP_035240.3

      Status: VALIDATED

      Source sequence(s)
      AL844178
      Consensus CDS
      CCDS18834.1
      UniProtKB/Swiss-Prot
      P97391, Q9QZU6
      UniProtKB/TrEMBL
      E9PZD1, Q6GTW1
      Related
      ENSMUSP00000099570.5, ENSMUST00000102512.11
      Conserved Domains (1) summary
      cd00125
      Location:21137
      PLA2c; Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a metal-dependent ...

    RNA

    1. NR_188945.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL844178

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      138526558..138590784 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163835.1XP_036019728.1  phospholipase A2 group V isoform X1

      Related
      ENSMUSP00000099569.2, ENSMUST00000102511.2
      Conserved Domains (1) summary
      cd00125
      Location:21137
      PLA2c; Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a metal-dependent ...
    2. XM_006538658.5XP_006538721.2  phospholipase A2 group V isoform X1

      Conserved Domains (1) summary
      cd00125
      Location:21137
      PLA2c; Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a metal-dependent ...
    3. XM_017320044.1XP_017175533.1  phospholipase A2 group V isoform X1

      UniProtKB/Swiss-Prot
      P97391, Q9QZU6
      UniProtKB/TrEMBL
      E9PZD1, Q6GTW1
      Conserved Domains (1) summary
      cd00125
      Location:21137
      PLA2c; Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a metal-dependent ...