U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Pip5k1b phosphatidylinositol-4-phosphate 5-kinase, type 1 beta [ Mus musculus (house mouse) ]

    Gene ID: 18719, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pip5k1bprovided by MGI
    Official Full Name
    phosphatidylinositol-4-phosphate 5-kinase, type 1 betaprovided by MGI
    Primary source
    MGI:MGI:107930
    See related
    Ensembl:ENSMUSG00000024867 AllianceGenome:MGI:107930
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    STM7; Pipk5b; PIP5KIbeta; PI4P5K-I[b]; PIP5K1-beta
    Summary
    Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity. Acts upstream of or within phosphatidylinositol biosynthetic process. Located in cytosol. Is expressed in several structures, including brain. Orthologous to human PIP5K1B (phosphatidylinositol-4-phosphate 5-kinase type 1 beta). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Note: This record was renamed from Pip5k1a to Pip5k1b to conform to the annotation of human. [03 Apr 2007]
    Expression
    Broad expression in large intestine adult (RPKM 14.5), genital fat pad adult (RPKM 9.3) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pip5k1b in Genome Data Viewer
    Location:
    19 B; 19 19.44 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (24272158..24533236, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (24294794..24555872, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5692 Neighboring gene frataxin Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene Neighboring gene phosphatidylinositol-4-phosphate 5-kinase, type 1 beta, opposite strand Neighboring gene STARR-seq mESC enhancer starr_45802 Neighboring gene predicted gene, 52399 Neighboring gene PP2A A alpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1 Neighboring gene STARR-seq mESC enhancer starr_45804 Neighboring gene STARR-seq mESC enhancer starr_45805 Neighboring gene predicted gene, 50341 Neighboring gene STARR-seq mESC enhancer starr_45806 Neighboring gene transmembrane protein 252 Neighboring gene phosphoglucomutase 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in uropod IEA
    Inferred from Electronic Annotation
    more info
     
    located_in uropod ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    phosphatidylinositol 4-phosphate 5-kinase type-1 beta
    Names
    68 kDa type I phosphatidylinositol 4-phosphate 5-kinase beta
    PIP5KI-beta
    phosphatidylinositol 4-phosphate 5-kinase type I beta
    ptdIns(4)P-5-kinase 1 beta
    NP_032872.1
    XP_006526826.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008846.3NP_032872.1  phosphatidylinositol 4-phosphate 5-kinase type-1 beta

      See identical proteins and their annotated locations for NP_032872.1

      Status: VALIDATED

      Source sequence(s)
      AC150898, AI844522, AK146100
      Consensus CDS
      CCDS37940.1
      UniProtKB/Swiss-Prot
      O70335, P70181, Q8JZY6
      Related
      ENSMUSP00000025800.9, ENSMUST00000025800.15
      Conserved Domains (1) summary
      cd17307
      Location:27400
      PIPKc_PIP5K1B; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase type-1 beta (PIP5K1beta) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      24272158..24533236 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526763.5XP_006526826.1  phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1

      See identical proteins and their annotated locations for XP_006526826.1

      UniProtKB/Swiss-Prot
      O70335, P70181, Q8JZY6
      Conserved Domains (1) summary
      cd17307
      Location:27400
      PIPKc_PIP5K1B; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase type-1 beta (PIP5K1beta) and similar proteins