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    Sp100 nuclear antigen Sp100 [ Mus musculus (house mouse) ]

    Gene ID: 20684, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sp100provided by MGI
    Official Full Name
    nuclear antigen Sp100provided by MGI
    Primary source
    MGI:MGI:109561
    See related
    Ensembl:ENSMUSG00000026222 AllianceGenome:MGI:109561
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A430075G10Rik
    Summary
    Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; chromo shadow domain binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including innate immune response; regulation of DNA-templated transcription; and regulation of signal transduction. Predicted to be located in cytoplasm and nuclear lumen. Predicted to be part of Mre11 complex. Predicted to be active in nucleus. Is expressed in eye; olfactory placode; and otic pit. Orthologous to human SP100 (SP100 nuclear antigen). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in thymus adult (RPKM 9.0), spleen adult (RPKM 7.8) and 20 other tissues See more
    Orthologs
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    Genomic context

    See Sp100 in Genome Data Viewer
    Location:
    1 C5; 1 43.6 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (85577683..85637719)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (85649948..85709998)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 7592 Neighboring gene STARR-seq mESC enhancer starr_01547 Neighboring gene predicted gene 2666 Neighboring gene STARR-seq mESC enhancer starr_01548 Neighboring gene predicted gene 2427 Neighboring gene STARR-positive B cell enhancer mm9_chr1:87441371-87441672 Neighboring gene STARR-seq mESC enhancer starr_01549 Neighboring gene Sp110 nuclear body protein Neighboring gene Sp140 nuclear body protein Neighboring gene STARR-seq mESC enhancer starr_01550 Neighboring gene STARR-seq mESC enhancer starr_01551 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:87584047-87584232 Neighboring gene STARR-positive B cell enhancer ABC_E1221 Neighboring gene STARR-positive B cell enhancer ABC_E323 Neighboring gene RIKEN cDNA A630001G21 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:87629249-87629446 Neighboring gene STARR-positive B cell enhancer ABC_E1551 Neighboring gene STARR-positive B cell enhancer ABC_E1999 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:87647325-87647478 Neighboring gene microRNA 8096

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromo shadow domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response, signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in maintenance of protein location ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endothelial cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of viral transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of Fas signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of Fas signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of extrinsic apoptotic signaling pathway via death domain receptors ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to cytokine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to retinoic acid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to type I interferon ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in telomere maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of Mre11 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Mre11 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear periphery ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    nuclear autoantigen Sp-100
    Names
    nuclear dot-associated Sp100 protein
    speckled 100 kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313712.1NP_001300641.1  nuclear autoantigen Sp-100 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks multiple 3' coding exons and extends past a splice site used in variant 1, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct, shorter C-terminus than isoform 1.
      Source sequence(s)
      AA162577, AC147806, AC161342, AK080004, U83630
      Consensus CDS
      CCDS83568.1
      UniProtKB/Swiss-Prot
      E9PY02, O35892, O35897, O88392, O88395
      UniProtKB/TrEMBL
      Q4FK53
      Related
      ENSMUSP00000118481.2, ENSMUST00000155094.8
      Conserved Domains (2) summary
      pfam01342
      Location:383458
      SAND; SAND domain
      pfam03172
      Location:24116
      Sp100; Sp100 domain
    2. NM_001313713.1NP_001300642.1  nuclear autoantigen Sp-100 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal in-frame exon and lacks multiple 3' coding exons and extends past a splice site used in variant 1, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AA162577, AC147806, AK152348, U83636
      Consensus CDS
      CCDS83569.1
      UniProtKB/TrEMBL
      Q3U876, Q6NTA3
      Related
      ENSMUSP00000116942.2, ENSMUST00000147552.8
      Conserved Domains (2) summary
      pfam01342
      Location:365440
      SAND; SAND domain
      pfam03172
      Location:24116
      Sp100; Sp100 domain
    3. NM_001313714.1NP_001300643.1  nuclear autoantigen Sp-100 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks multiple 3' coding exons and contains an alternate 3' terminal exon, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (4) has a distinct, shorter C-terminus than isoform 1.
      Source sequence(s)
      AC147806, AK146054
      Consensus CDS
      CCDS83567.1
      UniProtKB/TrEMBL
      E9Q4Y0, Q3UKD8, Q8C9H3
      Related
      ENSMUSP00000051705.9, ENSMUST00000054279.15
      Conserved Domains (1) summary
      pfam03172
      Location:24116
      Sp100; Sp100 domain
    4. NM_001372231.1NP_001359160.1  nuclear autoantigen Sp-100 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) represents the longest variant and encodes the longest isoform (5).
      Source sequence(s)
      AC147806, AC161342
      Conserved Domains (4) summary
      cd05501
      Location:552652
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      cd15626
      Location:484525
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:385458
      SAND; SAND domain
      pfam03172
      Location:23119
      HSR; HSR domain
    5. NM_001372232.1NP_001359161.1  nuclear autoantigen Sp-100 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC147806, AC161342
      Conserved Domains (4) summary
      cd05501
      Location:527627
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      cd15626
      Location:459500
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:360433
      SAND; SAND domain
      pfam03172
      Location:23119
      HSR; HSR domain
    6. NM_013673.4NP_038701.2  nuclear autoantigen Sp-100 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame segment compared to variant 5. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 5.
      Source sequence(s)
      AA277101, AC147806, AK083304, AV284523
      Consensus CDS
      CCDS35639.1
      UniProtKB/TrEMBL
      E9QA05, Q8C405
      Related
      ENSMUSP00000066399.5, ENSMUST00000066427.11
      Conserved Domains (3) summary
      cd05501
      Location:474574
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      pfam01342
      Location:383458
      SAND; SAND domain
      pfam03172
      Location:24116
      Sp100; Sp100 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      85577683..85637719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529283.5XP_006529346.2  nuclear autoantigen Sp-100 isoform X4

      Conserved Domains (4) summary
      cd05501
      Location:533633
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      cd15626
      Location:465506
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:366439
      SAND; SAND domain
      pfam03172
      Location:23119
      HSR; HSR domain
    2. XM_036163002.1XP_036018895.1  nuclear autoantigen Sp-100 isoform X6

      Conserved Domains (4) summary
      cd05501
      Location:508608
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      cd15626
      Location:440481
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:339414
      SAND; SAND domain
      pfam03172
      Location:23119
      HSR; HSR domain
    3. XM_017319442.3XP_017174931.1  nuclear autoantigen Sp-100 isoform X2

      Conserved Domains (4) summary
      cd05501
      Location:551651
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      cd15626
      Location:483524
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:385458
      SAND; SAND domain
      pfam03172
      Location:23119
      HSR; HSR domain
    4. XM_006529281.5XP_006529344.2  nuclear autoantigen Sp-100 isoform X1

      Conserved Domains (4) summary
      cd05501
      Location:551651
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      cd15626
      Location:484524
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:385458
      SAND; SAND domain
      pfam03172
      Location:23119
      HSR; HSR domain
    5. XM_006529282.5XP_006529345.2  nuclear autoantigen Sp-100 isoform X3

      Conserved Domains (4) summary
      cd05501
      Location:534634
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      cd15626
      Location:466507
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:367440
      SAND; SAND domain
      pfam03172
      Location:23119
      HSR; HSR domain
    6. XM_006529286.5XP_006529349.2  nuclear autoantigen Sp-100 isoform X5

      Conserved Domains (4) summary
      cd05501
      Location:509609
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      cd15626
      Location:441482
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:342415
      SAND; SAND domain
      pfam03172
      Location:23119
      HSR; HSR domain
    7. XM_017319443.3XP_017174932.1  nuclear autoantigen Sp-100 isoform X8

      UniProtKB/TrEMBL
      E9QA05
      Conserved Domains (3) summary
      pfam01342
      Location:385458
      SAND; SAND domain
      pfam03172
      Location:23119
      HSR; HSR domain
      cl02556
      Location:469501
      Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    8. XM_011247950.4XP_011246252.2  nuclear autoantigen Sp-100 isoform X9

      UniProtKB/TrEMBL
      Q4FK53
      Conserved Domains (2) summary
      pfam01342
      Location:385458
      SAND; SAND domain
      pfam03172
      Location:23119
      HSR; HSR domain
    9. XM_006529288.5XP_006529351.2  nuclear autoantigen Sp-100 isoform X7

      UniProtKB/TrEMBL
      E9QA05
      Related
      ENSMUSP00000122670.2, ENSMUST00000153574.8
      Conserved Domains (3) summary
      pfam01342
      Location:385458
      SAND; SAND domain
      pfam03172
      Location:23119
      HSR; HSR domain
      cl02556
      Location:470502
      Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.